A C2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

A C2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

Abstract A C 2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2′,5′-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. ­Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity fac...

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Veröffentlicht in:Synlett 2007-03, Vol.2007 (5), p.0725-0728
Hauptverfasser: Nguyen, Huy V., Motevalli, Majid, Richards, Christopher J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A C 2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2′,5′-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. ­Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (S) of up to 6.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-970764