Stereoselective Synthesis of 2,4-Disubstituted Thiochromans Using the Supported Reagent System ‘Na2CO3/SiO2-PPA/SiO2’
Abstract A simple and efficient method has been developed for the stereoselective synthesis of 2,4-disubstituted thiochromans from arylthiols and α,β-unsaturated aldehydes by using an acid- and a base-supported reagent system, Na 2 CO 3 /SiO 2 -PPA/SiO 2 . Michael addition of arylthiol to α,β-unsatu...
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| Veröffentlicht in: | Synlett 2007-02, Vol.2007 (3), p.0387-0390 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng ; jpn |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
A simple and efficient method has been developed for the stereoselective synthesis of 2,4-disubstituted thiochromans from arylthiols and α,β-unsaturated aldehydes by using an acid- and a base-supported reagent system, Na
2
CO
3
/SiO
2
-PPA/SiO
2
. Michael addition of arylthiol to α,β-unsaturated aldehydes was promoted by Na
2
CO
3
/SiO
2
, and then the product was cyclized in the presence of PPA/SiO
2
. |
|---|---|
| ISSN: | 0936-5214 1437-2096 |
| DOI: | 10.1055/s-2007-967935 |