Solvent-Free, Open-Vessel Microwave-Promoted Heck Couplings: From the mmol to the mol Scale

Solvent-Free, Open-Vessel Microwave-Promoted Heck Couplings: From the mmol to the mol Scale

Abstract The rapid, microwave-promoted Heck coupling of aryl iodides in open reaction vessels is presented and scale-up of the reactions to the mol scale demonstrated. Reactions are performed using 0.1 mol% palladium acetate as the catalyst, sodium carbonate and tributylamine as bases and tetrabutyl...

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Veröffentlicht in:Synlett 2006-11, Vol.2006 (18), p.2953-2958
Hauptverfasser: Leadbeater, Nicholas E., Williams, Victoria A., Barnard, Thomas M., Collins Jr, Michael J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The rapid, microwave-promoted Heck coupling of aryl iodides in open reaction vessels is presented and scale-up of the reactions to the mol scale demonstrated. Reactions are performed using 0.1 mol% palladium acetate as the catalyst, sodium carbonate and tributylamine as bases and tetrabutylammonium bromide as an additive.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-951512