Rapid Microwave-Assisted Syntheses of Derivatives of HIV-1 Entry Inhibitors

Rapid Microwave-Assisted Syntheses of Derivatives of HIV-1 Entry Inhibitors

ABSTRACT The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods.

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Veröffentlicht in:Synthesis (Stuttgart) 2006-03, Vol.2006 (5), p.807-812
Hauptverfasser: McFarland, Chris, Vicic, David A., Debnath, Asim Kumar
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-926339