Towards the Synthesis of the Skeleton of Salvianolic Acid D

Towards the Synthesis of the Skeleton of Salvianolic Acid D

ABSTRACT A successful synthesis of the acid part of salvianolic acid D is described (eight steps from isovanillin, 22% overall yield). The benzaldehyde key intermediate was obtained in six steps in 52% overall yield and was converted into the trimethylated precursor molecule using the Knoevenagel pr...

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Veröffentlicht in:Synthesis (Stuttgart) 2006-03, Vol.2006 (5), p.768-770
Hauptverfasser: Queffélec, Clémence, Bailly, Fabrice, Cotelle, Philippe
Format: Artikel
Sprache:eng
Schlagworte:
short paper
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Zusammenfassung:ABSTRACT A successful synthesis of the acid part of salvianolic acid D is described (eight steps from isovanillin, 22% overall yield). The benzaldehyde key intermediate was obtained in six steps in 52% overall yield and was converted into the trimethylated precursor molecule using the Knoevenagel procedure. Finally, the acid part of salvianolic acid D was obtained by the exhaustive deprotection of the methyl groups with boron tribromide.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-926332