Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Aminopyrimidines from a Stable Precursor
ABSTRACT An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vinamidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionaliz...
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| Veröffentlicht in: | Synthesis (Stuttgart) 2005-07, Vol.2005 (11), p.1817-1821 |
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| container_end_page | 1821 |
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| container_issue | 11 |
| container_start_page | 1817 |
| container_title | Synthesis (Stuttgart) |
| container_volume | 2005 |
| creator | Dousson, Cyril B. Heron, Nicola M. Hill, George B. |
| description | ABSTRACT
An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vinamidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks. |
| doi_str_mv | 10.1055/s-2005-865338 |
| format | Article |
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An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vinamidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks.</description><identifier>ISSN: 0039-7881</identifier><identifier>EISSN: 1437-210X</identifier><identifier>DOI: 10.1055/s-2005-865338</identifier><language>eng</language><ispartof>Synthesis (Stuttgart), 2005-07, Vol.2005 (11), p.1817-1821</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1518-4510cb63f44aac00c040d2c98abbc256d4639168d6807299d079b3d9a58364c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-865338.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2005-865338$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,27901,27902,54534,54535</link.rule.ids></links><search><creatorcontrib>Dousson, Cyril B.</creatorcontrib><creatorcontrib>Heron, Nicola M.</creatorcontrib><creatorcontrib>Hill, George B.</creatorcontrib><title>Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Aminopyrimidines from a Stable Precursor</title><title>Synthesis (Stuttgart)</title><addtitle>Synthesis</addtitle><description>ABSTRACT
An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vinamidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks.</description><issn>0039-7881</issn><issn>1437-210X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNotkEtOwzAYhC0EEqWwZO8DYPgdP2KzayteUiWQQhG7yLEd6pIHiuNFD8UlOBktZTWr-Wb0IXRJ4ZqCEDeRZACCKCkYU0doQjnLSUbh_RhNAJgmuVL0FJ3FuAGAPGN6gvybaZKpGo-LbTeu_RgsnqfQuNB94HnT2894i1fR16nBGSlSFccwptE7LMisDV3_8_21HUIbdgUfcT30LTa4GP-QL4O3aYj9cI5OatNEf_GfU7S6v3tdPJLl88PTYrYklgqqCBcUbCVZzbkxFsACB5dZrUxV2UxIxyXTVCon1e6-1g5yXTGnjVBMcsvYFF0duOM6-NaXmz4N3W6wpFDuFZWx3CsqD4rYL06pWfQ</recordid><startdate>20050715</startdate><enddate>20050715</enddate><creator>Dousson, Cyril B.</creator><creator>Heron, Nicola M.</creator><creator>Hill, George B.</creator><scope/></search><sort><creationdate>20050715</creationdate><title>Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Aminopyrimidines from a Stable Precursor</title><author>Dousson, Cyril B. ; Heron, Nicola M. ; Hill, George B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1518-4510cb63f44aac00c040d2c98abbc256d4639168d6807299d079b3d9a58364c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dousson, Cyril B.</creatorcontrib><creatorcontrib>Heron, Nicola M.</creatorcontrib><creatorcontrib>Hill, George B.</creatorcontrib><jtitle>Synthesis (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dousson, Cyril B.</au><au>Heron, Nicola M.</au><au>Hill, George B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Aminopyrimidines from a Stable Precursor</atitle><jtitle>Synthesis (Stuttgart)</jtitle><addtitle>Synthesis</addtitle><date>2005-07-15</date><risdate>2005</risdate><volume>2005</volume><issue>11</issue><spage>1817</spage><epage>1821</epage><pages>1817-1821</pages><issn>0039-7881</issn><eissn>1437-210X</eissn><abstract>ABSTRACT
An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vinamidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks.</abstract><doi>10.1055/s-2005-865338</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0039-7881 |
| ispartof | Synthesis (Stuttgart), 2005-07, Vol.2005 (11), p.1817-1821 |
| issn | 0039-7881 1437-210X |
| language | eng |
| recordid | cdi_thieme_journals_10_1055_s_2005_865338 |
| source | Thieme Connect Journals |
| title | Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Aminopyrimidines from a Stable Precursor |
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