Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Amino­pyrimidines from a Stable Precursor

Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Amino­pyrimidines from a Stable Precursor

ABSTRACT An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vin­amidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionaliz...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Synthesis (Stuttgart) 2005-07, Vol.2005 (11), p.1817-1821
Hauptverfasser: Dousson, Cyril B., Heron, Nicola M., Hill, George B.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ABSTRACT An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vin­amidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2005-865338