A Highly Regio- and Chemoselective Reductive Cleavage of Benzylidene Acetals with EtAlCl2-Et3SiH

Abstract A highly regio- and chemoselective reductive cleavage of benzylidene acetals derived from 1,2- and 1,3-diols was achieved under mild conditions using EtAlCl 2 -Et 3 SiH reagent system in good to excellent yields. Labile protecting groups such as N-Boc, N-Cbz and -OTBDMS are found to be stab...

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Veröffentlicht in:	Synlett 2004-03, Vol.2004 (4), p.647-650
Hauptverfasser:	Balakumar, Vijayakrishnan, Aravind, Appu, Baskaran, Sundarababu
Format:	Artikel
Sprache:	eng
Schlagworte:	letter
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description	Abstract A highly regio- and chemoselective reductive cleavage of benzylidene acetals derived from 1,2- and 1,3-diols was achieved under mild conditions using EtAlCl 2 -Et 3 SiH reagent system in good to excellent yields. Labile protecting groups such as N-Boc, N-Cbz and -OTBDMS are found to be stable under the reaction conditions.
doi_str_mv	10.1055/s-2004-817752
format	Article
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title	A Highly Regio- and Chemoselective Reductive Cleavage of Benzylidene Acetals with EtAlCl2-Et3SiH
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