A Highly Regio- and Chemoselective Reductive Cleavage of Benzylidene Acetals with EtAlCl2-Et3SiH
Abstract A highly regio- and chemoselective reductive cleavage of benzylidene acetals derived from 1,2- and 1,3-diols was achieved under mild conditions using EtAlCl 2 -Et 3 SiH reagent system in good to excellent yields. Labile protecting groups such as N-Boc, N-Cbz and -OTBDMS are found to be stab...
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| Veröffentlicht in: | Synlett 2004-03, Vol.2004 (4), p.647-650 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
A highly regio- and chemoselective reductive cleavage of benzylidene acetals derived from 1,2- and 1,3-diols was achieved under mild conditions using EtAlCl
2
-Et
3
SiH reagent system in good to excellent yields. Labile protecting groups such as N-Boc, N-Cbz and -OTBDMS are found to be stable under the reaction conditions. |
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| ISSN: | 0936-5214 1437-2096 |
| DOI: | 10.1055/s-2004-817752 |