Simple Preparation of N-Benzyl-β-aminohydroxamic Acids by 1,3-Dipolar Cycloaddition of Nitrones
ABSTRACT β-Aminohydroxamic acids 6A-D are prepared in 4 steps and 30-45% overall yield from nitrones 1A-D by 1,3-dipolar cycloaddition with phenyl vinyl ether, N-benzylation, thermal rearrangement, and nucleophilic substitution of the formed phenyl ester with hydroxylamine.
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| Veröffentlicht in: | Synthesis (Stuttgart) 2003-06, Vol.2003 (8) |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | ABSTRACT
β-Aminohydroxamic acids 6A-D are prepared in 4 steps and 30-45% overall
yield from nitrones 1A-D by 1,3-dipolar cycloaddition with phenyl
vinyl ether, N-benzylation, thermal rearrangement, and nucleophilic
substitution of the formed phenyl ester with hydroxylamine. |
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| ISSN: | 0039-7881 1437-210X |
| DOI: | 10.1055/s-2003-39412 |