The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols
Abstract A family of polymer-supported chiral acylation catalysts derived from N-4′-pyridinyl-α-methyl-proline has been synthesised and screened in the kinetic resolution of racemic alcohol 1. The best supported catalyst 4 behaves in most cases as its solution phase analog 13 in the enantioselective...
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| Veröffentlicht in: | Synlett 2003-04, Vol.2003 (5) |
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| container_issue | 5 |
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| container_title | Synlett |
| container_volume | 2003 |
| creator | Pelotier, Béatrice Priem, Ghislaine Campbell, Ian B. Macdonald, Simon J. Anson, Mike S. |
| description | Abstract
A family of polymer-supported chiral acylation catalysts derived
from N-4′-pyridinyl-α-methyl-proline
has been synthesised and screened in the kinetic resolution of racemic
alcohol 1. The best supported catalyst 4 behaves in most cases as its solution
phase analog 13 in the enantioselective
acylation of a range of alcohols and can be recycled without loss
of activity or selectivity. |
| doi_str_mv | 10.1055/s-2003-38354 |
| format | Article |
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A family of polymer-supported chiral acylation catalysts derived
from N-4′-pyridinyl-α-methyl-proline
has been synthesised and screened in the kinetic resolution of racemic
alcohol 1. The best supported catalyst 4 behaves in most cases as its solution
phase analog 13 in the enantioselective
acylation of a range of alcohols and can be recycled without loss
of activity or selectivity.</description><identifier>ISSN: 0936-5214</identifier><identifier>EISSN: 1437-2096</identifier><identifier>DOI: 10.1055/s-2003-38354</identifier><language>eng</language><subject>letter</subject><ispartof>Synlett, 2003-04, Vol.2003 (5)</ispartof><rights>Georg Thieme Verlag Stuttgart ˙ New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2003-38354.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2003-38354$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3016,27923,27924,54558,54559</link.rule.ids></links><search><creatorcontrib>Pelotier, Béatrice</creatorcontrib><creatorcontrib>Priem, Ghislaine</creatorcontrib><creatorcontrib>Campbell, Ian B.</creatorcontrib><creatorcontrib>Macdonald, Simon J.</creatorcontrib><creatorcontrib>Anson, Mike S.</creatorcontrib><title>The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols</title><title>Synlett</title><addtitle>Synlett</addtitle><description>Abstract
A family of polymer-supported chiral acylation catalysts derived
from N-4′-pyridinyl-α-methyl-proline
has been synthesised and screened in the kinetic resolution of racemic
alcohol 1. The best supported catalyst 4 behaves in most cases as its solution
phase analog 13 in the enantioselective
acylation of a range of alcohols and can be recycled without loss
of activity or selectivity.</description><subject>letter</subject><issn>0936-5214</issn><issn>1437-2096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNotkEFLAzEQhYMoWKs3f0DuEk02ye7mWBZrxaKl1vOSZmfZlHRTklTovzdVTwNvZt7jfQjdM_rIqJRPkRSUcsJrLsUFmjDBq6yo8hJNqOIlkQUT1-gmxh2lTNSKTtC4GQDPbYgJfx4PBx8SdPidrE7BdnY8ObwK3tkRSAfBfuddM9igHW500u6Uv3ofcMoeb_koWYPXEL07JutH7Hu81gb2WZ054wfv4i266rWLcPc_p-hr_rxpFmT58fLazJYkslolwnpdULPVpirLjkklSqULBaqWFZfAObAt7VkNDFhNK10KwTtT06IwshI895-ihz_fNFjYQ7vzxzDmwJbR9oyqje0ZVfuLiv8A2XpcGw</recordid><startdate>20030410</startdate><enddate>20030410</enddate><creator>Pelotier, Béatrice</creator><creator>Priem, Ghislaine</creator><creator>Campbell, Ian B.</creator><creator>Macdonald, Simon J.</creator><creator>Anson, Mike S.</creator><scope/></search><sort><creationdate>20030410</creationdate><title>The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols</title><author>Pelotier, Béatrice ; Priem, Ghislaine ; Campbell, Ian B. ; Macdonald, Simon J. ; Anson, Mike S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-s189t-1fa20cbac766d159469a29e985735e33e1b0f18e1e1807a6443dc8022c5743383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>letter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pelotier, Béatrice</creatorcontrib><creatorcontrib>Priem, Ghislaine</creatorcontrib><creatorcontrib>Campbell, Ian B.</creatorcontrib><creatorcontrib>Macdonald, Simon J.</creatorcontrib><creatorcontrib>Anson, Mike S.</creatorcontrib><jtitle>Synlett</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pelotier, Béatrice</au><au>Priem, Ghislaine</au><au>Campbell, Ian B.</au><au>Macdonald, Simon J.</au><au>Anson, Mike S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols</atitle><jtitle>Synlett</jtitle><addtitle>Synlett</addtitle><date>2003-04-10</date><risdate>2003</risdate><volume>2003</volume><issue>5</issue><issn>0936-5214</issn><eissn>1437-2096</eissn><abstract>Abstract
A family of polymer-supported chiral acylation catalysts derived
from N-4′-pyridinyl-α-methyl-proline
has been synthesised and screened in the kinetic resolution of racemic
alcohol 1. The best supported catalyst 4 behaves in most cases as its solution
phase analog 13 in the enantioselective
acylation of a range of alcohols and can be recycled without loss
of activity or selectivity.</abstract><doi>10.1055/s-2003-38354</doi></addata></record> |
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| identifier | ISSN: 0936-5214 |
| ispartof | Synlett, 2003-04, Vol.2003 (5) |
| issn | 0936-5214 1437-2096 |
| language | eng |
| recordid | cdi_thieme_journals_10_1055_s_2003_38354 |
| source | Thieme Connect Journals |
| subjects | letter |
| title | The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols |
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