The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols

The First Supported N-Pyridinyl Proline-derived Chiral Catalyst for the Kinetic Resolution of Racemic Alcohols

Abstract A family of polymer-supported chiral acylation catalysts derived from N-4′-pyridinyl-α-methyl-proline has been synthesised and screened in the kinetic resolution of racemic alcohol 1. The best supported catalyst 4 behaves in most cases as its solution phase analog 13 in the enantioselective...

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Veröffentlicht in:Synlett 2003-04, Vol.2003 (5)
Hauptverfasser: Pelotier, Béatrice, Priem, Ghislaine, Campbell, Ian B., Macdonald, Simon J., Anson, Mike S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract A family of polymer-supported chiral acylation catalysts derived from N-4′-pyridinyl-α-methyl-proline has been synthesised and screened in the kinetic resolution of racemic alcohol 1. The best supported catalyst 4 behaves in most cases as its solution phase analog 13 in the enantioselective acylation of a range of alcohols and can be recycled without loss of activity or selectivity.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-38354