Low Level of Circulating Activated Protein C Is a Risk Factor for Venous Thromboembolism

Summary The levels of circulating activated protein C (APC) reflect in vivo protein C activation. The aim of this study was to determine whether a low APC level is an independent risk factor for venous thromboembolism (VTE). We measured APC in 160 patients with a history of VTE and without recognize...

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Veröffentlicht in:	Thrombosis and haemostasis 2001-12, Vol.86 (6), p.1368-1373
Hauptverfasser:	España, Francisco, Vayá, Amparo, Mira, Yolanda, Medina, Pilar, Estellés, Amparo, Villa, Piedad, Falcó, Cristina, Aznar, Justo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha 1-Antitrypsin - analysis Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Enzyme Activation Female Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Pedigree Phenotype Platelet diseases and coagulopathies Prevalence Protein C Deficiency - epidemiology Protein C Deficiency - genetics Recurrence Review Article Spain - epidemiology Thrombin - metabolism Thrombophlebitis - blood Thrombophlebitis - epidemiology Thrombophlebitis - genetics
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Zusammenfassung:	Summary The levels of circulating activated protein C (APC) reflect in vivo protein C activation. The aim of this study was to determine whether a low APC level is an independent risk factor for venous thromboembolism (VTE). We measured APC in 160 patients with a history of VTE and without recognized thrombophilic defects, and in 199 healthy individuals. The mean (±SD) APC level was lower in patients (0.99 ± 0.44 ng/ml) than in controls (1.19 ± 0.41 ng/ml) (p
ISSN:	0340-6245 2567-689X
DOI:	10.1055/s-0037-1616737