Production of Tissue Factor Pathway Inhibitor in Cardiomyocytes and Its Upregulation by Interleukin-1

Tissue factor pathway inhibitor (TFPI) is a protease inhibitor that regulates tissue factor (TF)--initiated coagulation. We report here that cardiomyocytes express TFPI and the expression could be increased by Interleukin-1(IL-1beta). The TFPI expression in cardiomyocytes was confirmed by Northern b...

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Veröffentlicht in:	Thrombosis and haemostasis 2001-11, Vol.86 (5), p.1314-1319
Hauptverfasser:	Kereveur, Anne, Enjyoji, Keiichi, Masuda, Kazuyoshi, Yutani, Chikao, Kato, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation. Blood cells Blotting, Northern Cardiology. Vascular system Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Heart Humans Immunohistochemistry Interleukin-1 - pharmacology Lipoproteins - biosynthesis Lipoproteins - drug effects Lipoproteins - genetics Medical sciences Molecular and cellular biology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocarditis. Cardiomyopathies Myocardium - cytology Myocardium - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - drug effects RNA, Messenger - metabolism Scientific and Standardization Committee Communications Thromboplastin - genetics Thromboplastin - metabolism Umbilical Veins - cytology Up-Regulation - drug effects
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