Production of Tissue Factor Pathway Inhibitor in Cardiomyocytes and Its Upregulation by Interleukin-1

Tissue factor pathway inhibitor (TFPI) is a protease inhibitor that regulates tissue factor (TF)--initiated coagulation. We report here that cardiomyocytes express TFPI and the expression could be increased by Interleukin-1(IL-1beta). The TFPI expression in cardiomyocytes was confirmed by Northern b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Thrombosis and haemostasis 2001-11, Vol.86 (5), p.1314-1319
Hauptverfasser:	Kereveur, Anne, Enjyoji, Keiichi, Masuda, Kazuyoshi, Yutani, Chikao, Kato, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation. Blood cells Blotting, Northern Cardiology. Vascular system Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Heart Humans Immunohistochemistry Interleukin-1 - pharmacology Lipoproteins - biosynthesis Lipoproteins - drug effects Lipoproteins - genetics Medical sciences Molecular and cellular biology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocarditis. Cardiomyopathies Myocardium - cytology Myocardium - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - drug effects RNA, Messenger - metabolism Scientific and Standardization Committee Communications Thromboplastin - genetics Thromboplastin - metabolism Umbilical Veins - cytology Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Tissue factor pathway inhibitor (TFPI) is a protease inhibitor that regulates tissue factor (TF)--initiated coagulation. We report here that cardiomyocytes express TFPI and the expression could be increased by Interleukin-1(IL-1beta). The TFPI expression in cardiomyocytes was confirmed by Northern blotting with rat cardiomyocytes and also by immunostaining with anti-TFPI antibody on human heart specimens from patients either with sarcoidosis, myocarditis or myocardial infarction. The regulation of TFPI expression in cardiomyocytes differs from that in endothelial cells because TFPI expression is not induced in human endothelial cells by IL-1beta.
ISSN:	0340-6245 2567-689X
DOI:	10.1055/s-0037-1616070