Imbalance of Plasminogen Activator Inhibitor-I/ Tissue Plasminogen Activator and Tissue Factor/Tissue Factor Pathway Inhibitor in Young Japanese Men with Myocardial Infarction

Summary To evaluate the association between haemostatic parameters and increased risk of myocardial infarction (MI) at a young age, we measured fibrinogen, factor VII, antithrombin III, protein C, protein S, tissue factor (TF), free form tissue factor pathway inhibitor (TFPI), plasminogen, 2 -antipl...

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Veröffentlicht in:Thrombosis and haemostasis 2001-11, Vol.86 (5), p.1197-1203
Hauptverfasser: Saigo, Masahiko, Abe, Satoshi, Ogawa, Masakazu, Yamashita, Tsuminori, Biro, Sadatoshi, Minagoe, Shinichi, Maruyama, Ikuro, Tei, Chuwa
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Sprache:eng
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Zusammenfassung:Summary To evaluate the association between haemostatic parameters and increased risk of myocardial infarction (MI) at a young age, we measured fibrinogen, factor VII, antithrombin III, protein C, protein S, tissue factor (TF), free form tissue factor pathway inhibitor (TFPI), plasminogen, 2 -antiplasmin, tissue plasminogen activator (tPA), plasminogen activator inhibitor-I (PAI-I), and lipoprotein (a) in 140 young men with MI before age 45 and 150 age-matched healthy men. TF, TF/TFPI ratio, PAI-I, PAI-I/tPA ratio, plasminogen, and lipoprotein (a) in young MI patients were all significantly higher than controls, while TFPI, antithrombin III, and tPA were significantly lower (P
ISSN:0340-6245
2567-689X
DOI:10.1055/s-0037-1616051