Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase

Summary P-selectin is translocated from the α-granules to the surface of activated platelets where it participates in thrombosis and inflammation. We investigated the signaling pathways involved in thrombin-induced human platelet P-selectin expression. Assessed by flow cytometry, inhibition of prote...

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Veröffentlicht in:	Thrombosis and haemostasis 2003-06, Vol.89 (6), p.1016-1023
Hauptverfasser:	Libersan, Danielle, Merhi, Yahye
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - metabolism Blood Platelets - ultrastructure Fundamental and applied biological sciences. Psychology Humans Isoenzymes - physiology Molecular and cellular biology P-Selectin - analysis P-Selectin - biosynthesis Phosphatidylinositol 3-Kinases Platelet Platelets and Blood Cells Protein Kinase C - physiology Protein-Tyrosine Kinases Secretory Vesicles - secretion Signal Transduction Thrombin
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Beschreibung
Zusammenfassung:	Summary P-selectin is translocated from the α-granules to the surface of activated platelets where it participates in thrombosis and inflammation. We investigated the signaling pathways involved in thrombin-induced human platelet P-selectin expression. Assessed by flow cytometry, inhibition of protein kinase C (PKC) with chelerythrine reduced P-selectin expression by 66%, platelet/neutrophil binding, GPIIb/IIIa activation and aggregation (p
ISSN:	0340-6245 2567-689X
DOI:	10.1055/s-0037-1613403