Inflammatory profile of lower risk myelodysplastic syndromes

Inflammatory profile of lower risk myelodysplastic syndromes

Summary The precise link between inflammation and pathogenesis of myelodysplastic syndrome (MDS) is yet to be fully established. We developed a novel method to measure ASC/NLRP3 protein specks which are specific for the NLRP3 inflammasome only. We combined this with cytokine profiling to characteris...

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Veröffentlicht in:British journal of haematology 2024-09, Vol.205 (3), p.1044-1054
Hauptverfasser: Topping, Joanne, Taylor, Adele, Nadat, Fatima, Crouch, Simon, Ibbotson, Alice, Čermák, Jaroslav, Symeonidis, Argiris, Tatic, Aurelia, Langemeijer, Saskia, Hellström‐Lindberg, Eva, Culligan, Dominic, Garelius, Hege Gravdahl, Ashcroft, John, Nga, Emma, Parker, Jane, Kolade, Seye, McDermott, Michael F., De Witte, Theo, Bowen, David, Smith, Alexandra, Cargo, Catherine, Savic, Sinisa
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Blood transfusion
Case-Control Studies
Cytokines
Cytokines - blood
Erythrocytes
Female
Humans
Inflammasomes
inflammation
Inflammation - blood
Inflammatory diseases
Interferon
Male
MDS
Middle Aged
Myelodysplastic syndrome
Myelodysplastic Syndromes - blood
NLR Family, Pyrin Domain-Containing 3 Protein - blood
NLRP3 inflammasome
Pathogenesis
Tumor necrosis factor
Tumor necrosis factor-TNF
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Zusammenfassung:Summary The precise link between inflammation and pathogenesis of myelodysplastic syndrome (MDS) is yet to be fully established. We developed a novel method to measure ASC/NLRP3 protein specks which are specific for the NLRP3 inflammasome only. We combined this with cytokine profiling to characterise various inflammatory markers in a large cohort of patients with lower risk MDS in comparison to healthy controls and patients with defined autoinflammatory disorders (AIDs). The ASC/NLRP3 specks were significantly elevated in MDS patients compared to healthy controls (p 
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/bjh.19530