Towards more accurate pharmacogenomic variant effect predictions

Accurate variant interpretation has become a key bottleneck for the translation of an individual's pharmacogenome into actionable recommendations. We recommend an integrated use of multiplexed assays, structure-based predictions and biobank data to develop more accurate effect predictors.

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Bibliographische Detailangaben
Veröffentlicht in:	Pharmacogenomics 2023-11, Vol.24 (16), p.841-844
Hauptverfasser:	Park, Yoomi, M Lauschke, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	genomic medicine Medicin och hälsovetenskap personalized drug response precision medicine variant of unknown significance
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Accurate variant interpretation has become a key bottleneck for the translation of an individual's pharmacogenome into actionable recommendations. We recommend an integrated use of multiplexed assays, structure-based predictions and biobank data to develop more accurate effect predictors.
ISSN:	1462-2416 1744-8042 1744-8042
DOI:	10.2217/pgs-2023-0187