Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study
Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but the biological changes induced by ECT remain poorly understood. This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 protein...
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| Veröffentlicht in: | Biological psychiatry global open science 2023-10, Vol.3 (4), p.884-892 |
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| creator | Göteson, Andreas Clements, Caitlin C. Juréus, Anders Joas, Erik Holmén Larsson, Jessica Karlsson, Robert Nordenskjöld, Axel Pålsson, Erik Landén, Mikael |
| description | Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but the biological changes induced by ECT remain poorly understood.
This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 proteins in samples collected at 3 time points (T): just before the first ECT treatment session (T0), within 30 minutes after the first ECT session (T1), and just before the sixth ECT session (T2).
Using statistical models to account for repeated sampling, we identified 152 and 70 significantly ( |
| doi_str_mv | 10.1016/j.bpsgos.2022.11.005 |
| format | Article |
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This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 proteins in samples collected at 3 time points (T): just before the first ECT treatment session (T0), within 30 minutes after the first ECT session (T1), and just before the sixth ECT session (T2).
Using statistical models to account for repeated sampling, we identified 152 and 70 significantly (<5% false discovery rate) altered proteins at T1 and T2, respectively. The most pronounced alterations at T1 were transiently increased levels of prolactin, myoglobin, and kallikrein-6. However, most proteins had decreased levels at T1, with the largest effects observed for pro-epidermal growth factor, proto-oncogene tyrosine-protein kinase Src, tumor necrosis factor ligand superfamily member 14, sulfotransferase 1A1, early activation antigen CD69, and CD40 ligand. The change of several acutely altered proteins correlated with electric current and pulse frequency in a dose-response–like manner. Over a 5-session course of ECT, some acutely altered levels were sustained while others increased, e.g., serine protease 8 and chitinase-3-like protein 1. None of the studied protein biomarkers were associated with clinical response to ECT.
We report experimental data on alterations in the circulating proteome triggered by ECT in a clinical setting. The findings implicate hormonal signaling, immune response, apoptotic processes, and more. None of the findings were associated with clinical response to ECT.</description><identifier>ISSN: 2667-1743</identifier><identifier>EISSN: 2667-1743</identifier><identifier>DOI: 10.1016/j.bpsgos.2022.11.005</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>alpha ; Archival Report ; Biomarker ; Depression ; ECT ; efficacy ; epidermal-growth-factor ; inflammation ; injury ; interleukin-6 ; Longitudinal ; Major depressive episode ; Medicin och hälsovetenskap ; neuron-specific enolase ; Neurosciences ; Neurosciences & Neurology ; neurotrophic factor ; Neurovetenskaper ; prolactin response ; Proteomics ; Psychiatry</subject><ispartof>Biological psychiatry global open science, 2023-10, Vol.3 (4), p.884-892</ispartof><rights>2022 The Authors</rights><rights>2022 The Authors 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-aee0f6f1e5736c3b471737115f17dac771d2600c14564c70adc9cb474e6cc6e23</citedby><cites>FETCH-LOGICAL-c605t-aee0f6f1e5736c3b471737115f17dac771d2600c14564c70adc9cb474e6cc6e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593865/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593865/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109500$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/332317$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:237881534$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Göteson, Andreas</creatorcontrib><creatorcontrib>Clements, Caitlin C.</creatorcontrib><creatorcontrib>Juréus, Anders</creatorcontrib><creatorcontrib>Joas, Erik</creatorcontrib><creatorcontrib>Holmén Larsson, Jessica</creatorcontrib><creatorcontrib>Karlsson, Robert</creatorcontrib><creatorcontrib>Nordenskjöld, Axel</creatorcontrib><creatorcontrib>Pålsson, Erik</creatorcontrib><creatorcontrib>Landén, Mikael</creatorcontrib><title>Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study</title><title>Biological psychiatry global open science</title><description>Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but the biological changes induced by ECT remain poorly understood.
This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 proteins in samples collected at 3 time points (T): just before the first ECT treatment session (T0), within 30 minutes after the first ECT session (T1), and just before the sixth ECT session (T2).
Using statistical models to account for repeated sampling, we identified 152 and 70 significantly (<5% false discovery rate) altered proteins at T1 and T2, respectively. The most pronounced alterations at T1 were transiently increased levels of prolactin, myoglobin, and kallikrein-6. However, most proteins had decreased levels at T1, with the largest effects observed for pro-epidermal growth factor, proto-oncogene tyrosine-protein kinase Src, tumor necrosis factor ligand superfamily member 14, sulfotransferase 1A1, early activation antigen CD69, and CD40 ligand. The change of several acutely altered proteins correlated with electric current and pulse frequency in a dose-response–like manner. Over a 5-session course of ECT, some acutely altered levels were sustained while others increased, e.g., serine protease 8 and chitinase-3-like protein 1. None of the studied protein biomarkers were associated with clinical response to ECT.
We report experimental data on alterations in the circulating proteome triggered by ECT in a clinical setting. The findings implicate hormonal signaling, immune response, apoptotic processes, and more. None of the findings were associated with clinical response to ECT.</description><subject>alpha</subject><subject>Archival Report</subject><subject>Biomarker</subject><subject>Depression</subject><subject>ECT</subject><subject>efficacy</subject><subject>epidermal-growth-factor</subject><subject>inflammation</subject><subject>injury</subject><subject>interleukin-6</subject><subject>Longitudinal</subject><subject>Major depressive episode</subject><subject>Medicin och hälsovetenskap</subject><subject>neuron-specific enolase</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>neurotrophic factor</subject><subject>Neurovetenskaper</subject><subject>prolactin response</subject><subject>Proteomics</subject><subject>Psychiatry</subject><issn>2667-1743</issn><issn>2667-1743</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNp9kstu1DAUhiMEElXpG7Dwkk0GX2I7YQEatVOKNBVILWwtj3OS8eCJg51MNS_Ac9dDhksXzMI61jnff44vf5a9JnhGMBFvN7NVH1sfZxRTOiNkhjF_lp1RIWROZMGe_7N_mV3EuMEYU04YI_Qs-zl3AwQ9WN9FZDs0rAHdQRi36EvwA_gtoGvvnH-wXYsWDswQvPHdbnTR7gDdr5O436PGB6TRrd6keAV9gPirvOht9DW8Q3O09F1rh7G2nXbodnSDNdCl0eguJfevsheNdhEujvE8-3q9uL-8yZefP366nC9zIzAfcg2AG9EQ4JIJw1aFJJJJQnhDZK2NlKSmAmNDCi4KI7GuTWUSVYAwRgBl51k-9Y0P0I8r1Qe71WGvvLbqmPqedqAEr2RVJr76L98HX_8V_RZSJsuScFacnNWOvUqpdjxIGKMs3eMUf2W_zZUPbVqjIrjiGCf-w8QneAv14TmDdk-P-KTS2bVq_S7pecVKwVOHN8cOwf8YIQ5qa6MB53QHfoyKliVlVBBaJbSYUBN8jAGaP3MIVgcfqo2afKgOPlSEqOTDJHs_ySB96s5CUNFY6AzUNiQvqdrb0w0eAUBn7lk</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Göteson, Andreas</creator><creator>Clements, Caitlin C.</creator><creator>Juréus, Anders</creator><creator>Joas, Erik</creator><creator>Holmén Larsson, Jessica</creator><creator>Karlsson, Robert</creator><creator>Nordenskjöld, Axel</creator><creator>Pålsson, Erik</creator><creator>Landén, Mikael</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>AABEP</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D91</scope><scope>ZZAVC</scope><scope>F1U</scope></search><sort><creationdate>20231001</creationdate><title>Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study</title><author>Göteson, Andreas ; Clements, Caitlin C. ; Juréus, Anders ; Joas, Erik ; Holmén Larsson, Jessica ; Karlsson, Robert ; Nordenskjöld, Axel ; Pålsson, Erik ; Landén, Mikael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-aee0f6f1e5736c3b471737115f17dac771d2600c14564c70adc9cb474e6cc6e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>alpha</topic><topic>Archival Report</topic><topic>Biomarker</topic><topic>Depression</topic><topic>ECT</topic><topic>efficacy</topic><topic>epidermal-growth-factor</topic><topic>inflammation</topic><topic>injury</topic><topic>interleukin-6</topic><topic>Longitudinal</topic><topic>Major depressive episode</topic><topic>Medicin och hälsovetenskap</topic><topic>neuron-specific enolase</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>neurotrophic factor</topic><topic>Neurovetenskaper</topic><topic>prolactin response</topic><topic>Proteomics</topic><topic>Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Göteson, Andreas</creatorcontrib><creatorcontrib>Clements, Caitlin C.</creatorcontrib><creatorcontrib>Juréus, Anders</creatorcontrib><creatorcontrib>Joas, Erik</creatorcontrib><creatorcontrib>Holmén Larsson, Jessica</creatorcontrib><creatorcontrib>Karlsson, Robert</creatorcontrib><creatorcontrib>Nordenskjöld, Axel</creatorcontrib><creatorcontrib>Pålsson, Erik</creatorcontrib><creatorcontrib>Landén, Mikael</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Örebro universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Örebro universitet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Biological psychiatry global open science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Göteson, Andreas</au><au>Clements, Caitlin C.</au><au>Juréus, Anders</au><au>Joas, Erik</au><au>Holmén Larsson, Jessica</au><au>Karlsson, Robert</au><au>Nordenskjöld, Axel</au><au>Pålsson, Erik</au><au>Landén, Mikael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study</atitle><jtitle>Biological psychiatry global open science</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>3</volume><issue>4</issue><spage>884</spage><epage>892</epage><pages>884-892</pages><issn>2667-1743</issn><eissn>2667-1743</eissn><abstract>Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but the biological changes induced by ECT remain poorly understood.
This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 proteins in samples collected at 3 time points (T): just before the first ECT treatment session (T0), within 30 minutes after the first ECT session (T1), and just before the sixth ECT session (T2).
Using statistical models to account for repeated sampling, we identified 152 and 70 significantly (<5% false discovery rate) altered proteins at T1 and T2, respectively. The most pronounced alterations at T1 were transiently increased levels of prolactin, myoglobin, and kallikrein-6. However, most proteins had decreased levels at T1, with the largest effects observed for pro-epidermal growth factor, proto-oncogene tyrosine-protein kinase Src, tumor necrosis factor ligand superfamily member 14, sulfotransferase 1A1, early activation antigen CD69, and CD40 ligand. The change of several acutely altered proteins correlated with electric current and pulse frequency in a dose-response–like manner. Over a 5-session course of ECT, some acutely altered levels were sustained while others increased, e.g., serine protease 8 and chitinase-3-like protein 1. None of the studied protein biomarkers were associated with clinical response to ECT.
We report experimental data on alterations in the circulating proteome triggered by ECT in a clinical setting. The findings implicate hormonal signaling, immune response, apoptotic processes, and more. None of the findings were associated with clinical response to ECT.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.bpsgos.2022.11.005</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological psychiatry global open science, 2023-10, Vol.3 (4), p.884-892 |
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| subjects | alpha Archival Report Biomarker Depression ECT efficacy epidermal-growth-factor inflammation injury interleukin-6 Longitudinal Major depressive episode Medicin och hälsovetenskap neuron-specific enolase Neurosciences Neurosciences & Neurology neurotrophic factor Neurovetenskaper prolactin response Proteomics Psychiatry |
| title | Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study |
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