Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study

Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but the biological changes induced by ECT remain poorly understood. This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 protein...

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Veröffentlicht in:	Biological psychiatry global open science 2023-10, Vol.3 (4), p.884-892
Hauptverfasser:	Göteson, Andreas, Clements, Caitlin C., Juréus, Anders, Joas, Erik, Holmén Larsson, Jessica, Karlsson, Robert, Nordenskjöld, Axel, Pålsson, Erik, Landén, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha Archival Report Biomarker Depression ECT efficacy epidermal-growth-factor inflammation injury interleukin-6 Longitudinal Major depressive episode Medicin och hälsovetenskap neuron-specific enolase Neurosciences Neurosciences & Neurology neurotrophic factor Neurovetenskaper prolactin response Proteomics Psychiatry
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Zusammenfassung:	Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but the biological changes induced by ECT remain poorly understood. This study investigated alterations in blood serum proteins in 309 patients receiving ECT for a major depressive episode. We analyzed 201 proteins in samples collected at 3 time points (T): just before the first ECT treatment session (T0), within 30 minutes after the first ECT session (T1), and just before the sixth ECT session (T2). Using statistical models to account for repeated sampling, we identified 152 and 70 significantly (
ISSN:	2667-1743 2667-1743
DOI:	10.1016/j.bpsgos.2022.11.005