Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain

Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain

A pre-clinical study has been carried out for the utilization of magnetite (Fe 3O 4) nanoparticles as a diagnostic tracer for MRI. Surfactant-coated Fe 3O 4 nanoparticles have been synthesized by a chemical coprecipitation method with a narrow particle size of around 6 nm. Preliminary experiments de...

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Veröffentlicht in:Journal of magnetism and magnetic materials 2001, Vol.225 (1), p.256-261
Hauptverfasser: Kim, D.K., Zhang, Y., Kehr, J., Klason, T., Bjelke, B., Muhammed, M.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Brain
Contrast agent
Contrast media. Radiopharmaceuticals
galanin
gene-expression
Iron oxide
kinetics
Medical sciences
Medicin och hälsovetenskap
MRI
Nanoparticles
Pharmacology. Drug treatments
Rat
Superparamagnetism
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Beschreibung
Zusammenfassung:A pre-clinical study has been carried out for the utilization of magnetite (Fe 3O 4) nanoparticles as a diagnostic tracer for MRI. Surfactant-coated Fe 3O 4 nanoparticles have been synthesized by a chemical coprecipitation method with a narrow particle size of around 6 nm. Preliminary experiments demonstrated the feasibility of using superparamagnetic Fe 3O 4 nanoparticles as contrast agents in MR imaging.
ISSN:0304-8853
1873-4766
DOI:10.1016/S0304-8853(00)01255-5