Imaging endogenous dopamine occupancy of the D2 receptor in rat brain with [11C]MNPA

Imaging endogenous dopamine occupancy of the D2 receptor in rat brain with [11C]MNPA

Conclusions: Assuming that there was no upregulation in the density of the D2 receptor during the short period of DA depletion, these results suggest that a significant proportion of striatal D2 receptors in the high affinity state is occupied by endogenous dopamine under baseline conditions.

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Veröffentlicht in:NEUROIMAGE 2006, Vol.31, p.T119-T119
Hauptverfasser: Seneca, Nicholas, Liow, J.S., Zoghbi, S., Musachio, J.L., Hong, J., Pike, V.W., Halldin, C., Innis, R.B.
Format: Artikel
Sprache:eng
Schlagworte:
Dopamine
Medicin och hälsovetenskap
Parkinson's disease
Rodents
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Zusammenfassung:Conclusions: Assuming that there was no upregulation in the density of the D2 receptor during the short period of DA depletion, these results suggest that a significant proportion of striatal D2 receptors in the high affinity state is occupied by endogenous dopamine under baseline conditions.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.105