Alkylation and acylation of basic salts of anthranilic acid

Alkylation and acylation of basic salts of anthranilic acid

Basic salts of anthranilic acid were found to exhibit O-nucleophilicity toward alkylating and acylating reagents. The O-nucleophilicity of basic anthranilic acid salts was documented, analyzed, and utilized in synthesis. Specifically substitutions leading to esters instead of secondary amines, and f...

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Veröffentlicht in:Tetrahedron letters 2004, Vol.45 (5), p.969-972
Hauptverfasser: Wiklund, Per, Bergman, Jan
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Alkylation
Anthranilic acid
Medicin och hälsovetenskap
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Zusammenfassung:Basic salts of anthranilic acid were found to exhibit O-nucleophilicity toward alkylating and acylating reagents. The O-nucleophilicity of basic anthranilic acid salts was documented, analyzed, and utilized in synthesis. Specifically substitutions leading to esters instead of secondary amines, and formation of anthranilic acid anhydrides were studied.
ISSN:0040-4039
1359-8562
1873-3581
DOI:10.1016/j.tetlet.2003.11.111