A New Picornavirus Isolated from Bank Voles (Clethrionomys glareolus)

A New Picornavirus Isolated from Bank Voles (Clethrionomys glareolus)

A previously unknown picornavirus was isolated from bank voles (Clethrionomys glareolus). Electron microscopy images and sequence data of the prototype isolate, named Ljungan virus, showed that it is a picornavirus. The amino acid sequences of predicted Ljungan virus capsid proteins VP2 and VP3 were...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1999-03, Vol.255 (1), p.86-93
Hauptverfasser: Niklasson, Bo, Kinnunen, Leena, Hörnfeldt, Birger, Hörling, Jan, Benemar, Charlotte, Olof Hedlund, Kjell, Matskova, Ludmila, Hyypiä, Timo, Winberg, Gösta
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Antigens, Viral - immunology
Arvicolinae - virology
Base Sequence
Capsid - genetics
Capsid Proteins
Cardiovirus
Cardiovirus - immunology
Clethrionomys glareolus
Cross Reactions
Cytopathogenic Effect, Viral
DNA, Viral
Enterovirus B, Human - immunology
Human echovirus 22
Humans
Ljungan virus
Medicin och hälsovetenskap
Molecular Sequence Data
Picornaviridae
Picornaviridae - classification
Picornaviridae - genetics
Picornaviridae - isolation & purification
Picornaviridae - ultrastructure
Sequence Homology, Amino Acid
Virion - ultrastructure
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Beschreibung
Zusammenfassung:A previously unknown picornavirus was isolated from bank voles (Clethrionomys glareolus). Electron microscopy images and sequence data of the prototype isolate, named Ljungan virus, showed that it is a picornavirus. The amino acid sequences of predicted Ljungan virus capsid proteins VP2 and VP3 were closely related to the human pathogen echovirus 22 (approximately 70% similarity). A partial 5′ noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1998.9557