CRBP I and CRABP I localisation during olfactory nerve development

Retinoic acid appears to play a role during the formation of the olfactory system. Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system. Our results indicate that RA produced by t...

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Veröffentlicht in:	Brain research. Developmental brain research 1999-04, Vol.114 (1), p.121-126
Hauptverfasser:	Gustafson, Anne-Lee, Eriksson, Ulf, Dencker, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - chemistry CRABP I CRBP I Embryogenesis Medicin och hälsovetenskap Mice Mice, Inbred C57BL Mouse Olfactory Olfactory Bulb - chemistry Olfactory Bulb - cytology Olfactory Bulb - embryology Olfactory Nerve - chemistry Olfactory Nerve - cytology Olfactory Nerve - embryology Olfactory Receptor Neurons - chemistry Olfactory Receptor Neurons - physiology Olfactory Receptor Neurons - ultrastructure Receptors, Retinoic Acid - analysis Retinoic acid Retinol-Binding Proteins - analysis Retinol-Binding Proteins, Cellular Tretinoin - physiology
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Zusammenfassung:	Retinoic acid appears to play a role during the formation of the olfactory system. Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system. Our results indicate that RA produced by the CRBP I-expressing `glia-like' cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons.
ISSN:	0165-3806
DOI:	10.1016/S0165-3806(99)00014-0