Identification of an anti-mycobacterial domain in NK-lysin and granulysin

NK-lysin and granulysin are homologous cationic anti-bacterial peptides produced by pig and human cytolytic lymphocytes, respectively. The solution structure of NK-lysin comprises five amphipathic alpha-helices. To investigate the properties of a helix-loop-helix region postulated to be a membrane-d...

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Veröffentlicht in:	Biochemical journal 1999-12, Vol.344 Pt 3 (3), p.845-849
Hauptverfasser:	Andreu, D, Carreño, C, Linde, C, Boman, H G, Andersson, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antigens, Differentiation, T-Lymphocyte - chemistry Antigens, Differentiation, T-Lymphocyte - pharmacology Bacillus megaterium - drug effects Circular Dichroism Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Peptide Fragments - chemical synthesis Protein Structure, Secondary Proteolipids - chemistry Proteolipids - pharmacology Pseudomonas aeruginosa - drug effects Pulmonary Surfactants - chemistry Pulmonary Surfactants - pharmacology Staphylococcus aureus - drug effects Swine
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