The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TRalpha 1 reduced them, whereas deletion of TRbeta actually increased them. These results could not be attributed to altered levels of hormones in the blood, general al...

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Veröffentlicht in:	Nature neuroscience 2000-05, Vol.3 (5), p.472-475
Hauptverfasser:	Pfaff, Donald W, Dellovade, Tammy L, Chan, John, Vennstrom, Bjorn, Forrest, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Estradiol - analogs & derivatives Estradiol - blood Estradiol - pharmacology estrogen genes Estrogens Estrogens - blood Estrogens - pharmacology Female Females Gene Deletion Gene expression Genes Genetic aspects Genotype & phenotype Hormone receptors Hormones Hypothalamus Male Males Medicin och hälsovetenskap Mice Mice, Inbred Strains Mice, Knockout Neurosciences Organ Size - drug effects Oxytocin - analysis Paraventricular Hypothalamic Nucleus - chemistry Paraventricular Hypothalamic Nucleus - cytology Physiological aspects Posture Preoptic Area - chemistry Preoptic Area - cytology Progesterone - pharmacology Psychological aspects Receptors, Estrogen - analysis Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - physiology Sex Sexual behavior Sexual Behavior, Animal - drug effects Thyroid gland thyroid hormone receptors Thyroxine - blood Triiodothyronine - blood Uterus - drug effects Uterus - growth & development Vasopressins - analysis
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Zusammenfassung:	The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TRalpha 1 reduced them, whereas deletion of TRbeta actually increased them. These results could not be attributed to altered levels of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/74846