In vitro chemosensitivity testing in acute non lymphocytic leukemia using the bioluminescence ATP assay

The ATP assay is a short term in vitro chemosensitivity assay where the amount of viable cells are determined by their content of ATP. The aim of the study was to compare the in vitro results of six cytostatic drugs to the clinical outcome in 83 acute non-lymphocytic leukemia (ANLL) patients. The se...

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Veröffentlicht in:	Leukemia research 2000-05, Vol.24 (5), p.445-452
Hauptverfasser:	Möllgård, Lars, Tidefelt, Ulf, Sundman-Engberg, Britt, Löfgren, Christina, Paul, Christer
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adenosine Triphosphate - analysis Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Biological Assay Bioluminiscence ATP assay Cell Survival Chemosensitivity Cytotoxicity Daunorubicin - pharmacology Daunorubicin - therapeutic use Drug resistance Drug Resistance, Microbial Drug Resistance, Neoplasm Humans Leukemia, Myeloid - drug therapy Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Luminescent Measurements Myeloid leukemia Sensitivity and Specificity Tumor Cells, Cultured
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Zusammenfassung:	The ATP assay is a short term in vitro chemosensitivity assay where the amount of viable cells are determined by their content of ATP. The aim of the study was to compare the in vitro results of six cytostatic drugs to the clinical outcome in 83 acute non-lymphocytic leukemia (ANLL) patients. The secondary ANLL at diagnosis showed an in vitro resistance to daunorubicin that was significantly higher compared to de novo ANLL at diagnosis ( P
ISSN:	0145-2126 1873-5835
DOI:	10.1016/S0145-2126(00)00003-5