Altered expression of members of the IGF-axis in hepatoblastomas

Previous reports have demonstrated that expression of insulin-like growth factor 2 ( IGF2 ) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding no...

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Veröffentlicht in:	British journal of cancer 2000-05, Vol.82 (9), p.1561-1567
Hauptverfasser:	Gray, S G, Eriksson, T, Ekström, C, Holm, S, Schweinitz, D von, Kogner, P, Sandstedt, B, Pietsch, T, Ekstöm, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell division Connective tissue Drug Resistance Epidemiology Gastroenterology. Liver. Pancreas. Abdomen Genes Genes, Tumor Suppressor Hepatoblastoma - genetics Humans Insulin Insulin-Like Growth Factor Binding Proteins - genetics Insulin-like growth factors Liver Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical research Medical sciences Molecular Medicine Muscle Proteins - genetics Oncology Pediatrics Proteins Receptors, Somatomedin - genetics Regular regular-article RNA, Long Noncoding RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated Somatomedins - genetics Tumors
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Zusammenfassung:	Previous reports have demonstrated that expression of insulin-like growth factor 2 ( IGF2 ) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development. © 2000 Cancer Research Campaign
ISSN:	0007-0920 1532-1827 1532-1827
DOI:	10.1054/bjoc.1999.1179