Impact of moxifloxacin versus clarithromycin on normal oropharyngeal microflora

A multiple-dose, randomized, double-blind, controlled, cross-over trial was performed in 12 healthy male subjects in order to investigate the effect of a 7-day treatment with moxifloxacin (400 mg orally, once daily) versus clarithromycin (500 mg orally, twice daily) on the normal oropharyngeal micro...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2000-07, Vol.19 (7), p.548-550
Hauptverfasser: BEYER, G, HIEMER-BAU, M, ZIEGE, S, EDLUND, C, LODE, H, NORD, C. E
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Sprache:eng
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Zusammenfassung:A multiple-dose, randomized, double-blind, controlled, cross-over trial was performed in 12 healthy male subjects in order to investigate the effect of a 7-day treatment with moxifloxacin (400 mg orally, once daily) versus clarithromycin (500 mg orally, twice daily) on the normal oropharyngeal microflora. Moxifloxacin caused significant reductions in levels of alpha-streptococci and Neisseria cocci during the treatment period, while the numbers of gram-negative anaerobic bacteria increased markedly during moxifloxacin administration. Clarithromycin administration caused a suppression of micrococci and corynebacteria, while no significant changes were recorded in the anaerobic microflora. No new colonizing moxifloxacin-resistant strains were isolated during the investigation period.
ISSN:0934-9723
1435-4373
DOI:10.1007/s100960000304