Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-h...
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| Veröffentlicht in: | Neuroscience letters 2000-10, Vol.293 (2), p.87-90 |
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| container_title | Neuroscience letters |
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| creator | Bretillon, Lionel Sidén, Åke Wahlund, Lars-Olof Lütjohann, Dieter Minthon, Lennart Crisby, Milita Hillert, Jan Groth, Carl-Gustav Diczfalusy, Ulf Björkhem, Ingemar |
| description | The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6–10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (−43%,
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| doi_str_mv | 10.1016/S0304-3940(00)01466-X |
| format | Article |
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P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke, multiple sclerosis and primary brain tumors had levels not significantly different from those of controls. The conditions leading to reduced plasma levels of 24S-hydroxycholesterol had no significant effect on plasma levels of another side-chain oxidized oxysterol, 27-hydroxycholesterol. Except for conditions characterized by very marked destruction of the central nervous system, different severe neurological diseases seem to have relatively small effects on the flux of 24S-hydroxycholesterol from the brain.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(00)01466-X</identifier><identifier>PMID: 11027840</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>24S-^AHydroxycholesterol ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease - blood ; Alzheimer's disease ; Basic Medicine ; Biological and medical sciences ; Brain ; Brain - metabolism ; Brain Death - blood ; Central nervous system ; Cholesterol - blood ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Glioma - blood ; Guillain-Barre Syndrome - blood ; Humans ; Hydroxycholesterols - blood ; Life Sciences ; Liver - metabolism ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Medicinska och farmaceutiska grundvetenskaper ; Meningitis, Viral - blood ; Middle Aged ; Multiple Sclerosis - blood ; Nervous System Diseases - blood ; Neurological diseases ; Neurology ; Neurons and Cognition ; Neurosciences ; Neurovetenskaper ; Oxysterols ; Sex Factors ; Stroke - blood</subject><ispartof>Neuroscience letters, 2000-10, Vol.293 (2), p.87-90</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-b1be7d6731b8a19b994206dbe269e28896cb4c6465473b887a0b4468f63edeef3</citedby><cites>FETCH-LOGICAL-c614t-b1be7d6731b8a19b994206dbe269e28896cb4c6465473b887a0b4468f63edeef3</cites><orcidid>0000-0002-6957-100X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439400001466X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1524416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11027840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02694412$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1296867$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1942034$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Bretillon, Lionel</creatorcontrib><creatorcontrib>Sidén, Åke</creatorcontrib><creatorcontrib>Wahlund, Lars-Olof</creatorcontrib><creatorcontrib>Lütjohann, Dieter</creatorcontrib><creatorcontrib>Minthon, Lennart</creatorcontrib><creatorcontrib>Crisby, Milita</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><creatorcontrib>Groth, Carl-Gustav</creatorcontrib><creatorcontrib>Diczfalusy, Ulf</creatorcontrib><creatorcontrib>Björkhem, Ingemar</creatorcontrib><title>Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6–10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (−43%,
P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke, multiple sclerosis and primary brain tumors had levels not significantly different from those of controls. The conditions leading to reduced plasma levels of 24S-hydroxycholesterol had no significant effect on plasma levels of another side-chain oxidized oxysterol, 27-hydroxycholesterol. Except for conditions characterized by very marked destruction of the central nervous system, different severe neurological diseases seem to have relatively small effects on the flux of 24S-hydroxycholesterol from the brain.</description><subject>24S-^AHydroxycholesterol</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer's disease</subject><subject>Basic Medicine</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain Death - blood</subject><subject>Central nervous system</subject><subject>Cholesterol - blood</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Glioma - blood</subject><subject>Guillain-Barre Syndrome - blood</subject><subject>Humans</subject><subject>Hydroxycholesterols - blood</subject><subject>Life Sciences</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicinska och farmaceutiska grundvetenskaper</subject><subject>Meningitis, Viral - blood</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - blood</subject><subject>Nervous System Diseases - blood</subject><subject>Neurological diseases</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Neurosciences</subject><subject>Neurovetenskaper</subject><subject>Oxysterols</subject><subject>Sex Factors</subject><subject>Stroke - blood</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1rFDEUhoModl39CcpciNiL0ZNMvuZKSlErLCpUoXchyZxxo9md6WRm6_57M-7S4oUUckg4POczLyHPKbyhQOXbS6iAl1XN4TXAKVAuZXn1gCyoVqxUtWIPyeIWOSFPUvoJAIIK_picUApMaQ4L8vlrtGlji4g7jKno2oLxy3K9b4bu996vu4hpxKGLRdgWvR0DbsdU3IRxXWxxyv7uR_A2Fk1IaBOmp-RRa2PCZ8d7Sb5_eP_t_KJcffn46fxsVXpJ-Vg66lA1UlXUaUtrV9ecgWwcMlkj07qW3nEvuRRcVU5rZcFxLnUrK2wQ22pJykPedIP95Ew_hI0d9qazwRxdv_ILjQSouM786r98nPpsLtsc4DWwRihuOBXCcOaoca1ujK-tbHOTeaUupzs9pFvb-E-ui7OVmX2QB-Gcsh3N7KsD2w_d9ZTXaTYheYzRbrGbklGsYpoJcS9IlRKVzB0siTiAfuhSGrC9bYGCmcVh_orDzD9vIJ9ZHOYqx704FpjcBpu7qKMaMvDyCNiUf7Ud7NaHdMcJlmea6787YFkxuAs4mOSzMDw2YUA_mqYL93TyBya71Mg</recordid><startdate>20001027</startdate><enddate>20001027</enddate><creator>Bretillon, Lionel</creator><creator>Sidén, Åke</creator><creator>Wahlund, Lars-Olof</creator><creator>Lütjohann, Dieter</creator><creator>Minthon, Lennart</creator><creator>Crisby, Milita</creator><creator>Hillert, Jan</creator><creator>Groth, Carl-Gustav</creator><creator>Diczfalusy, Ulf</creator><creator>Björkhem, Ingemar</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D95</scope><orcidid>https://orcid.org/0000-0002-6957-100X</orcidid></search><sort><creationdate>20001027</creationdate><title>Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases</title><author>Bretillon, Lionel ; Sidén, Åke ; Wahlund, Lars-Olof ; Lütjohann, Dieter ; Minthon, Lennart ; Crisby, Milita ; Hillert, Jan ; Groth, Carl-Gustav ; Diczfalusy, Ulf ; Björkhem, Ingemar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c614t-b1be7d6731b8a19b994206dbe269e28896cb4c6465473b887a0b4468f63edeef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>24S-^AHydroxycholesterol</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - blood</topic><topic>Alzheimer's disease</topic><topic>Basic Medicine</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Brain Death - blood</topic><topic>Central nervous system</topic><topic>Cholesterol - blood</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Glioma - blood</topic><topic>Guillain-Barre Syndrome - blood</topic><topic>Humans</topic><topic>Hydroxycholesterols - blood</topic><topic>Life Sciences</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicinska och farmaceutiska grundvetenskaper</topic><topic>Meningitis, Viral - blood</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - blood</topic><topic>Nervous System Diseases - blood</topic><topic>Neurological diseases</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Neurosciences</topic><topic>Neurovetenskaper</topic><topic>Oxysterols</topic><topic>Sex Factors</topic><topic>Stroke - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bretillon, Lionel</creatorcontrib><creatorcontrib>Sidén, Åke</creatorcontrib><creatorcontrib>Wahlund, Lars-Olof</creatorcontrib><creatorcontrib>Lütjohann, Dieter</creatorcontrib><creatorcontrib>Minthon, Lennart</creatorcontrib><creatorcontrib>Crisby, Milita</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><creatorcontrib>Groth, Carl-Gustav</creatorcontrib><creatorcontrib>Diczfalusy, Ulf</creatorcontrib><creatorcontrib>Björkhem, Ingemar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Lunds universitet</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bretillon, Lionel</au><au>Sidén, Åke</au><au>Wahlund, Lars-Olof</au><au>Lütjohann, Dieter</au><au>Minthon, Lennart</au><au>Crisby, Milita</au><au>Hillert, Jan</au><au>Groth, Carl-Gustav</au><au>Diczfalusy, Ulf</au><au>Björkhem, Ingemar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2000-10-27</date><risdate>2000</risdate><volume>293</volume><issue>2</issue><spage>87</spage><epage>90</epage><pages>87-90</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6–10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (−43%,
P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke, multiple sclerosis and primary brain tumors had levels not significantly different from those of controls. The conditions leading to reduced plasma levels of 24S-hydroxycholesterol had no significant effect on plasma levels of another side-chain oxidized oxysterol, 27-hydroxycholesterol. Except for conditions characterized by very marked destruction of the central nervous system, different severe neurological diseases seem to have relatively small effects on the flux of 24S-hydroxycholesterol from the brain.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11027840</pmid><doi>10.1016/S0304-3940(00)01466-X</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6957-100X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2000-10, Vol.293 (2), p.87-90 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_600348 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 24S-^AHydroxycholesterol Adult Age Factors Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer's disease Basic Medicine Biological and medical sciences Brain Brain - metabolism Brain Death - blood Central nervous system Cholesterol - blood Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Glioma - blood Guillain-Barre Syndrome - blood Humans Hydroxycholesterols - blood Life Sciences Liver - metabolism Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Meningitis, Viral - blood Middle Aged Multiple Sclerosis - blood Nervous System Diseases - blood Neurological diseases Neurology Neurons and Cognition Neurosciences Neurovetenskaper Oxysterols Sex Factors Stroke - blood |
| title | Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases |
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