Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-h...

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Veröffentlicht in:Neuroscience letters 2000-10, Vol.293 (2), p.87-90
Hauptverfasser: Bretillon, Lionel, Sidén, Åke, Wahlund, Lars-Olof, Lütjohann, Dieter, Minthon, Lennart, Crisby, Milita, Hillert, Jan, Groth, Carl-Gustav, Diczfalusy, Ulf, Björkhem, Ingemar
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Sprache:eng
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Zusammenfassung:The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6–10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (−43%, P
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)01466-X