Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-h...
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Veröffentlicht in: | Neuroscience letters 2000-10, Vol.293 (2), p.87-90 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6–10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (−43%,
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ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/S0304-3940(00)01466-X |