Cholecystokinin-8 (CCK-8) has no effect on heart rate in rats lacking CCK-A receptors

Heart rate responses to i.v. administration of cholecystokinin-8 (CCK-8) were investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCK-A receptors and control Long-Evans Tokushima Otsuka (LETO) rats. The heart rate decreased after i.v. administration of 3 nmol·kg − 1 of CCK-8 in LE...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2001-08, Vol.22 (8), p.1279-1284
Hauptverfasser:	Kurosawa, Mieko, Iijima, Setsu, Funakoshi, Akihiro, Kawanami, Takako, Miyasaka, Kyoko, Bucinskaite, Violeta, Lundeberg, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrium Benzodiazepinones - pharmacology Blotting, Southern Bradycardia Cholecystokinin Devazepide - pharmacology DNA, Complementary - metabolism Dose-Response Relationship, Drug Heart Atria - metabolism Heart rate Heart Rate - drug effects Hormone Antagonists - pharmacology Long-Evans Tokushima Otsuka (LETO) rats Male Medicin och hälsovetenskap Otsuka Long-Evans Tokushima Fatty (OLETF) rats Phenylurea Compounds - pharmacology Polymerase Chain Reaction Rats Rats, Inbred OLETF Rats, Long-Evans Receptor, Cholecystokinin A Receptors, Cholecystokinin - biosynthesis Receptors, Cholecystokinin - genetics Receptors, Cholecystokinin - physiology RNA, Messenger - metabolism Sincalide - metabolism Sincalide - pharmacology Time Factors Type A CCK receptors Ventricle
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Zusammenfassung:	Heart rate responses to i.v. administration of cholecystokinin-8 (CCK-8) were investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCK-A receptors and control Long-Evans Tokushima Otsuka (LETO) rats. The heart rate decreased after i.v. administration of 3 nmol·kg − 1 of CCK-8 in LETO rats, but not in OLETF rats. Bradycardia in the LETO rats disappeared after treatment with MK-329, but not after treatment with L-365,260. The expression of CCK-A receptor precursor mRNA was found exclusively in the atrium in LETO rats. These results suggest that CCK-8 decreases heart rate via CCK-A receptors located in the atrium of the rats.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/S0196-9781(01)00452-1