Evidence of Linkage with HLA-DR in DRB115-Negative Families with Multiple Sclerosis

Evidence of Linkage with HLA-DR in DRB115-Negative Families with Multiple Sclerosis

The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed in 542 sib pairs with MS and in their families. By genotyping 1,978 individuals for HLA-DRB1 alleles, we confirmed the well-established association of MS with HLA-DRB1*15 ( HLA-DRB1*1501 and HLA-DRB5*0101), by...

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Veröffentlicht in:American journal of human genetics 2001-10, Vol.69 (4), p.900-903
Hauptverfasser: Ligers, Arturs, Dyment, David A., Willer, Cristen J., Sadovnick, A. Dessa, Ebers, George, Risch, Neil, Hillert, Jan
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Chromosome Mapping
Gene Frequency - genetics
Genetic Linkage - genetics
Genetic Predisposition to Disease - genetics
Haplotypes - genetics
histocompatibility antigen HLA
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Linkage Disequilibrium - genetics
Medicin och hälsovetenskap
Multiple Sclerosis - genetics
Nuclear Family
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Zusammenfassung:The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed in 542 sib pairs with MS and in their families. By genotyping 1,978 individuals for HLA-DRB1 alleles, we confirmed the well-established association of MS with HLA-DRB1*15 ( HLA-DRB1*1501 and HLA-DRB5*0101), by the transmission/disequilibrium test (χ 2=138.3; P
ISSN:0002-9297
1537-6605
DOI:10.1086/323480