Genetic susceptibility to MS : a second stage analysis in Canadian MS families

Genetic susceptibility to MS : a second stage analysis in Canadian MS families

Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and America...

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Veröffentlicht in:Neurogenetics 2001-07, Vol.3 (3), p.145-151
Hauptverfasser: DYMENT, David A, WILLER, Cristen J, KASTRUKOFF, Lorne, OGER, Joel, METZ, Luanne, WARREN, Sharon, HADER, Walter, POWER, Cristopher, AUTY, Anthony, NATH, Avindra, NELSON, Robert, FREEDMAN, Mark, SCOTT, Beverly, BRUNET, Donald, PAULSETH, John E, RICE, George, O'CONNOR, Paul, DUQUETTE, Pierre, LAPIERRE, Yves, FRANCIS, Gordon, BOUCHARD, Jean-Pierre, MURRAY, T. John, BHAN, Virender, ARMSTRONG, Holly, MAXNER, Charles, PRYSE-PHILLIPS, William, STEFANELLI, Mark, SADOVNICK, A. Dessa, RISCH, Neil, EBERS, George C, LIGERS, Arturs, HILLERT, Jan, PATY, Donald W, HASHIMOTO, Stanley, DEVONSHIRE, Virginia, HOOGE, John
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Canada
Family
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Genomes
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Linkage Disequilibrium
Male
Medical sciences
Multiple Sclerosis - genetics
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Nuclear Family
Software
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Zusammenfassung:Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
ISSN:1364-6745
1364-6753
DOI:10.1007/s100480100113