HIV subtypes and recombination strains-strategies for induction of immune responses in man

Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor–ligand interactions. We identified a direct interaction between HIV-1 envelope...

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Veröffentlicht in:	Vaccine 2002-05, Vol.20 (15), p.1988-1993
Hauptverfasser:	Wahren, B, Ljungberg, K, Rollman, E, Levi, M, Zuber, B, Kjerrström Zuber, A, Hinkula, J, Leandersson, A.-C, Calarota, S, Hejdeman, B, Bratt, G, Sandström, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer AIDS Vaccines - immunology Amino Acid Sequence Animals Antigen Presentation Biological and medical sciences Clinical Trials as Topic Cross Reactions Double-Blind Method Fundamental and applied biological sciences. Psychology Genes, env HIV HIV Antibodies - biosynthesis HIV Antibodies - immunology HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism HIV Envelope Protein gp160 - immunology HIV subtypes HIV-1 - classification HIV-1 - genetics HIV-1 - immunology Human viral diseases Humans Immunity, Cellular Immunization Infectious diseases Leukemia Virus, Murine - genetics Leukemia Virus, Murine - immunology Medical sciences Mice Mice, Inbred C57BL Microbiology Molecular Sequence Data Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - metabolism Prospective Studies Protein Binding Protein Structure, Tertiary Reassortant Viruses - immunology Receptors, CXCR4 - chemistry Receptors, CXCR4 - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Structure-Activity Relationship T-Lymphocyte Subsets - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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Zusammenfassung:	Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor–ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular receptor at the amino acid level. Both the viral subtype and its tropism appeared to influence inhibition of infection. Genetic immunization induced new cytotoxic responses while proteins appeared to efficiently boost previous responses. One HIV-1 subtype B antigen was strongly immunogenic in a human immunotherapeutic trial and permitted better survival at 2 years of the study in patients with poor prognosis.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/S0264-410X(02)00084-1