Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. The effect of...
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| Veröffentlicht in: | International journal of epidemiology 2003-02, Vol.32 (1), p.60-63 |
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| creator | TAIOLI, E GASPARI, L HIRVONEN, A HUSGAFVEL-PURSIAINEN, K KALINA, I KREMERS, P LE MARCHAND, L LONDON, S RANNUG, A ROMKES, M SCHOKET, B SEIDEGARD, J BENHAMOU, S STRANGE, R. C STACKER, I TO-FIGUERAS, J GARTE, S BOFFETTA, P BROCKMOLLER, J BUTKIEWICZ, D CASCORBI, I CLAPPER, M. L DOLZAN, V HAUGEN, A |
| description | A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk.
The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and |
| doi_str_mv | 10.1093/ije/dyg001 |
| format | Article |
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The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and </=45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls.
There was a marginally significant association between lung cancer and GSTT1 null genotype (OR=1.2; 95% CI:1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR=4.7 95% CI:1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers.
These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages.</description><identifier>ISSN: 0300-5771</identifier><identifier>ISSN: 1464-3685</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyg001</identifier><identifier>PMID: 12690010</identifier><identifier>CODEN: IJEPBF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Age of Onset ; Biological and medical sciences ; Case-Control Studies ; Chi-Square Distribution ; Cytochrome P-450 CYP1A1 ; Cytochrome P-450 CYP1A1 - genetics ; Databases, Factual ; Factor Analysis, Statistical ; Female ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Genetic Predisposition to Disease ; Glutathione Transferase ; Glutathione Transferase - genetics ; Health Sciences ; Humans ; Hälsovetenskap ; Life Sciences ; Lung Neoplasms ; Lung Neoplasms - genetics ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Pneumology ; Polymorphism, Genetic ; Public Health, Global Health, Social Medicine and Epidemiology ; Risk Factors ; Santé publique et épidémiologie ; Smoking ; Smoking - adverse effects ; Tumors of the respiratory system and mediastinum</subject><ispartof>International journal of epidemiology, 2003-02, Vol.32 (1), p.60-63</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Feb 2003</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-bde738f0514b2e83fd04c10f29da8ecb291685b22ba93bc673b75c6fd39ee45d3</citedby><cites>FETCH-LOGICAL-c586t-bde738f0514b2e83fd04c10f29da8ecb291685b22ba93bc673b75c6fd39ee45d3</cites><orcidid>0000-0003-4911-5290</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14690042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12690010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00266872$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/313041$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1957682$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>TAIOLI, E</creatorcontrib><creatorcontrib>GASPARI, L</creatorcontrib><creatorcontrib>HIRVONEN, A</creatorcontrib><creatorcontrib>HUSGAFVEL-PURSIAINEN, K</creatorcontrib><creatorcontrib>KALINA, I</creatorcontrib><creatorcontrib>KREMERS, P</creatorcontrib><creatorcontrib>LE MARCHAND, L</creatorcontrib><creatorcontrib>LONDON, S</creatorcontrib><creatorcontrib>RANNUG, A</creatorcontrib><creatorcontrib>ROMKES, M</creatorcontrib><creatorcontrib>SCHOKET, B</creatorcontrib><creatorcontrib>SEIDEGARD, J</creatorcontrib><creatorcontrib>BENHAMOU, S</creatorcontrib><creatorcontrib>STRANGE, R. C</creatorcontrib><creatorcontrib>STACKER, I</creatorcontrib><creatorcontrib>TO-FIGUERAS, J</creatorcontrib><creatorcontrib>GARTE, S</creatorcontrib><creatorcontrib>BOFFETTA, P</creatorcontrib><creatorcontrib>BROCKMOLLER, J</creatorcontrib><creatorcontrib>BUTKIEWICZ, D</creatorcontrib><creatorcontrib>CASCORBI, I</creatorcontrib><creatorcontrib>CLAPPER, M. L</creatorcontrib><creatorcontrib>DOLZAN, V</creatorcontrib><creatorcontrib>HAUGEN, A</creatorcontrib><title>Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk.
The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and </=45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls.
There was a marginally significant association between lung cancer and GSTT1 null genotype (OR=1.2; 95% CI:1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR=4.7 95% CI:1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers.
These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Cytochrome P-450 CYP1A1</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Databases, Factual</subject><subject>Factor Analysis, Statistical</subject><subject>Female</subject><subject>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</subject><subject>Genetic Predisposition to Disease</subject><subject>Glutathione Transferase</subject><subject>Glutathione Transferase - genetics</subject><subject>Health Sciences</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>Life Sciences</subject><subject>Lung Neoplasms</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Pneumology</subject><subject>Polymorphism, Genetic</subject><subject>Public Health, Global Health, Social Medicine and Epidemiology</subject><subject>Risk Factors</subject><subject>Santé publique et épidémiologie</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0300-5771</issn><issn>1464-3685</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kc-LEzEUx4Mobl29-AdIELzIjpuXZDKTYym6K1R2wXrwFJLJm3bq_OgmHZf-96bM4OLBw-Ml4ZPPI_kS8hbYJ2BaXDd7vPanLWPwjCxAKpkJVebPyYIJxrK8KOCCvIpxnwAppX5JLoArnXZsQe7uh_bUDeGwa2IXadPT1c97WMIVvfm--Ta1DVDbe9qO_ZZWtq8wUIft8EiPO6R2i3SoqczpCW2Ir8mL2rYR38z9kvz48nmzus3WdzdfV8t1VuWlOmbOYyHKmuUgHcdS1J7JCljNtbclVo5rSE9wnDurhatUIVyRV6r2QiPK3ItLkk3e-IiH0ZlDaDobTmawjZmPfqUVmlwzLiHx6__y7XhI5VKdLzCZC-2VMliq0kiuaqO9RwOFBCiVAytZ0l1Nup1t_3HdLtem6SOGzjDGlSoL_vs8_f2EH8LwMGI8mv0whj59kOGgIQeliwR9nKAqDDEGrP-KgZlz0CYFbaagE_xuNo6uQ_-Ezskm4MMM2FjZtg4puCY-cfLMSS7-AMPrrOg</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>TAIOLI, E</creator><creator>GASPARI, L</creator><creator>HIRVONEN, A</creator><creator>HUSGAFVEL-PURSIAINEN, K</creator><creator>KALINA, I</creator><creator>KREMERS, P</creator><creator>LE MARCHAND, L</creator><creator>LONDON, S</creator><creator>RANNUG, A</creator><creator>ROMKES, M</creator><creator>SCHOKET, B</creator><creator>SEIDEGARD, J</creator><creator>BENHAMOU, S</creator><creator>STRANGE, R. 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L</creator><creator>DOLZAN, V</creator><creator>HAUGEN, A</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><general>Oxford University Press (OUP)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>1XC</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-4911-5290</orcidid></search><sort><creationdate>20030201</creationdate><title>Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years</title><author>TAIOLI, E ; GASPARI, L ; HIRVONEN, A ; HUSGAFVEL-PURSIAINEN, K ; KALINA, I ; KREMERS, P ; LE MARCHAND, L ; LONDON, S ; RANNUG, A ; ROMKES, M ; SCHOKET, B ; SEIDEGARD, J ; BENHAMOU, S ; STRANGE, R. C ; STACKER, I ; TO-FIGUERAS, J ; GARTE, S ; BOFFETTA, P ; BROCKMOLLER, J ; BUTKIEWICZ, D ; CASCORBI, I ; CLAPPER, M. 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L</creatorcontrib><creatorcontrib>DOLZAN, V</creatorcontrib><creatorcontrib>HAUGEN, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAIOLI, E</au><au>GASPARI, L</au><au>HIRVONEN, A</au><au>HUSGAFVEL-PURSIAINEN, K</au><au>KALINA, I</au><au>KREMERS, P</au><au>LE MARCHAND, L</au><au>LONDON, S</au><au>RANNUG, A</au><au>ROMKES, M</au><au>SCHOKET, B</au><au>SEIDEGARD, J</au><au>BENHAMOU, S</au><au>STRANGE, R. C</au><au>STACKER, I</au><au>TO-FIGUERAS, J</au><au>GARTE, S</au><au>BOFFETTA, P</au><au>BROCKMOLLER, J</au><au>BUTKIEWICZ, D</au><au>CASCORBI, I</au><au>CLAPPER, M. L</au><au>DOLZAN, V</au><au>HAUGEN, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>32</volume><issue>1</issue><spage>60</spage><epage>63</epage><pages>60-63</pages><issn>0300-5771</issn><issn>1464-3685</issn><eissn>1464-3685</eissn><coden>IJEPBF</coden><abstract>A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk.
The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and </=45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls.
There was a marginally significant association between lung cancer and GSTT1 null genotype (OR=1.2; 95% CI:1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR=4.7 95% CI:1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers.
These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12690010</pmid><doi>10.1093/ije/dyg001</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-4911-5290</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adult Age of Onset Biological and medical sciences Case-Control Studies Chi-Square Distribution Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 - genetics Databases, Factual Factor Analysis, Statistical Female Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Genetic Predisposition to Disease Glutathione Transferase Glutathione Transferase - genetics Health Sciences Humans Hälsovetenskap Life Sciences Lung Neoplasms Lung Neoplasms - genetics Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Pneumology Polymorphism, Genetic Public Health, Global Health, Social Medicine and Epidemiology Risk Factors Santé publique et épidémiologie Smoking Smoking - adverse effects Tumors of the respiratory system and mediastinum |
| title | Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years |
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