Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years

A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. The effect of...

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Veröffentlicht in:	International journal of epidemiology 2003-02, Vol.32 (1), p.60-63
Hauptverfasser:	TAIOLI, E, GASPARI, L, HIRVONEN, A, HUSGAFVEL-PURSIAINEN, K, KALINA, I, KREMERS, P, LE MARCHAND, L, LONDON, S, RANNUG, A, ROMKES, M, SCHOKET, B, SEIDEGARD, J, BENHAMOU, S, STRANGE, R. C, STACKER, I, TO-FIGUERAS, J, GARTE, S, BOFFETTA, P, BROCKMOLLER, J, BUTKIEWICZ, D, CASCORBI, I, CLAPPER, M. L, DOLZAN, V, HAUGEN, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Biological and medical sciences Case-Control Studies Chi-Square Distribution Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 - genetics Databases, Factual Factor Analysis, Statistical Female Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Genetic Predisposition to Disease Glutathione Transferase Glutathione Transferase - genetics Health Sciences Humans Hälsovetenskap Life Sciences Lung Neoplasms Lung Neoplasms - genetics Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Pneumology Polymorphism, Genetic Public Health, Global Health, Social Medicine and Epidemiology Risk Factors Santé publique et épidémiologie Smoking Smoking - adverse effects Tumors of the respiratory system and mediastinum
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Beschreibung
Zusammenfassung:	A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and
ISSN:	0300-5771 1464-3685 1464-3685
DOI:	10.1093/ije/dyg001