The autoimmune T and B cell repertoires in monozygotic twins discordant for myasthenia gravis

Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasth...

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Veröffentlicht in:	Journal of neuroimmunology 2004-03, Vol.148 (1), p.183-191
Hauptverfasser:	Kakoulidou, M., Åhlberg, R., Yi, Q., Giscombe, R., Pirskanen, R., Lefvert, A.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies, Anti-Idiotypic - blood Antibodies, Anti-Idiotypic - immunology Antibodies, Monoclonal - blood Antibodies, Monoclonal - immunology Auto antibodies Autoantigens - metabolism Autoimmunity - genetics Autoimmunity - physiology B-lymphocyte B-Lymphocytes - immunology B-Lymphocytes - virology Blood Cells - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Cell Line Cell Transformation, Viral - immunology Cytokines - secretion Female Follow-Up Studies Herpesvirus 4, Human HLA-DR Antigens - metabolism Humans Leukocyte Common Antigens Longitudinal Studies Medicin och hälsovetenskap Mice Mice, Inbred C57BL Middle Aged Myasthenia gravis Myasthenia Gravis - immunology Myasthenia Gravis - pathology Myasthenia Gravis - virology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Cholinergic - blood Receptors, Cholinergic - immunology T lymphocyte T-Lymphocytes - immunology T-Lymphocytes - virology Twin Twin Studies as Topic Twins, Monozygotic
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Beschreibung
Zusammenfassung:	Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very similar autoantibody repertoires. IgG fractions from both healthy and myasthenic twins had the same capacity to decrease the free acetylcholine receptor content in mice after passive transfer. In comparison with their myasthenic sisters, the healthy twins had lower T cell responses against the acetylcholine receptor.
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2003.09.019