Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-induced antiangiogenesis

We have recently reported the identification of kringle 1-5 (K1-5) of plasminogen as a potent and specific inhibitor of angiogenesis and tumor growth. Here, we show that K1-5 bound to endothelial cell surface ATP synthase and triggered caspase-mediated endothelial cell apoptosis. Induction of endoth...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-05, Vol.64 (10), p.3679-3686
Hauptverfasser:	VEITONMÄKI, Niina, RENHAI CAO, WU, Lin-Hua, MOSER, Tammy L, BO LI, PIZZO, Salvatore V, ZHIVOTOVSKY, Boris, YIHAI CAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Animals Antineoplastic agents Apoptosis - drug effects Apoptosis - physiology ATP Synthetase Complexes - metabolism Biological and medical sciences Caspase Inhibitors Caspases - metabolism Chick Embryo Cornea - blood supply Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Enzyme Activation - drug effects Fibrosarcoma - blood supply Fibrosarcoma - drug therapy Fibrosarcoma - enzymology Humans Isoenzymes Kringles Male Medical sciences Medicin och hälsovetenskap Mice Mice, Inbred C57BL Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - pathology Neovascularization, Physiologic - drug effects Pharmacology. Drug treatments Plasminogen - metabolism Plasminogen - pharmacology Tumors
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