Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population
The major identified risk factor for lung cancer is tobacco smoking. We identified previously the possible modifying influence of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population. The present study, extended by several study subjects and with analyses for polymorphisms in G...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-06, Vol.13 (6), p.908-914 |
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| creator | ALEXANDRIE, Anna-Karin NYBERG, Fredrik WARHOLM, Margareta RANNUG, Agneta |
| description | The major identified risk factor for lung cancer is tobacco smoking. We identified previously the possible modifying influence
of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population. The present study, extended by several study subjects and with
analyses for polymorphisms in GSTT1 and NQO1 , includes 524 lung cancer cases and 530 control subjects. No evidence for an influence of genetic polymorphisms in CYP1A1 , GSTM1 , GSTT1 , and NQO1 on lung cancer risk overall was found. In smokers, there was, however, a suggestion that the variant CYP1A1 and NQO1 genotypes may confer an increased risk for squamous cell carcinoma. In ever smokers, the homozygously deleted GSTM1 ( GSTM1*O/*O ) genotype was significantly associated with increased risk of small cell carcinoma (adjusted odds ratio 2.72, 95% confidence
interval 1.32-5.90). The risks noted for the variant CYP1A1 genotypes and the GSTM1*O/*O genotype seemed to be restricted to light smokers. The GSTT1*O/*O genotype also appeared to be a possible risk factor in light smokers, whereas, in heavy smokers, this genotype was associated
with decreased risk for lung cancer overall (odds ratio 0.36, 95% confidence interval 0.13-0.99). Due to the multiple comparisons
made, we cannot exclude the possibility that some of these associations may represent chance findings. |
| doi_str_mv | 10.1158/1055-9965.908.13.6 |
| format | Article |
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of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population. The present study, extended by several study subjects and with
analyses for polymorphisms in GSTT1 and NQO1 , includes 524 lung cancer cases and 530 control subjects. No evidence for an influence of genetic polymorphisms in CYP1A1 , GSTM1 , GSTT1 , and NQO1 on lung cancer risk overall was found. In smokers, there was, however, a suggestion that the variant CYP1A1 and NQO1 genotypes may confer an increased risk for squamous cell carcinoma. In ever smokers, the homozygously deleted GSTM1 ( GSTM1*O/*O ) genotype was significantly associated with increased risk of small cell carcinoma (adjusted odds ratio 2.72, 95% confidence
interval 1.32-5.90). The risks noted for the variant CYP1A1 genotypes and the GSTM1*O/*O genotype seemed to be restricted to light smokers. The GSTT1*O/*O genotype also appeared to be a possible risk factor in light smokers, whereas, in heavy smokers, this genotype was associated
with decreased risk for lung cancer overall (odds ratio 0.36, 95% confidence interval 0.13-0.99). Due to the multiple comparisons
made, we cannot exclude the possibility that some of these associations may represent chance findings.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.908.13.6</identifier><identifier>PMID: 15184245</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Small Cell - epidemiology ; Carcinoma, Small Cell - genetics ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - genetics ; Case-Control Studies ; Cytochrome P-450 CYP1A1 - genetics ; Dose-Response Relationship, Drug ; Female ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase - genetics ; Humans ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Male ; Medical sciences ; Middle Aged ; NAD(P)H Dehydrogenase (Quinone) - genetics ; Pneumology ; Polymorphism, Genetic ; Risk Factors ; Smoking - adverse effects ; Smoking - genetics ; Sweden - epidemiology ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2004-06, Vol.13 (6), p.908-914</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-692001ec5731f15936cd3ce9821ed982c98afe6de88abfd8f66aa8a16f5e17143</citedby><cites>FETCH-LOGICAL-c399t-692001ec5731f15936cd3ce9821ed982c98afe6de88abfd8f66aa8a16f5e17143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3342,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15836587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15184245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1930782$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>ALEXANDRIE, Anna-Karin</creatorcontrib><creatorcontrib>NYBERG, Fredrik</creatorcontrib><creatorcontrib>WARHOLM, Margareta</creatorcontrib><creatorcontrib>RANNUG, Agneta</creatorcontrib><title>Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>The major identified risk factor for lung cancer is tobacco smoking. We identified previously the possible modifying influence
of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population. The present study, extended by several study subjects and with
analyses for polymorphisms in GSTT1 and NQO1 , includes 524 lung cancer cases and 530 control subjects. No evidence for an influence of genetic polymorphisms in CYP1A1 , GSTM1 , GSTT1 , and NQO1 on lung cancer risk overall was found. In smokers, there was, however, a suggestion that the variant CYP1A1 and NQO1 genotypes may confer an increased risk for squamous cell carcinoma. In ever smokers, the homozygously deleted GSTM1 ( GSTM1*O/*O ) genotype was significantly associated with increased risk of small cell carcinoma (adjusted odds ratio 2.72, 95% confidence
interval 1.32-5.90). The risks noted for the variant CYP1A1 genotypes and the GSTM1*O/*O genotype seemed to be restricted to light smokers. The GSTT1*O/*O genotype also appeared to be a possible risk factor in light smokers, whereas, in heavy smokers, this genotype was associated
with decreased risk for lung cancer overall (odds ratio 0.36, 95% confidence interval 0.13-0.99). Due to the multiple comparisons
made, we cannot exclude the possibility that some of these associations may represent chance findings.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - epidemiology</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Case-Control Studies</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NAD(P)H Dehydrogenase (Quinone) - genetics</subject><subject>Pneumology</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - genetics</subject><subject>Sweden - epidemiology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU2P0zAQhiMEYpeFP8AB-cJyIcWOa8c-rgKUlQq70HLgZLnOeGuaxMFuqPbAf8dpysfF86Fn3rHmzbLnBM8IYeINwYzlUnI2k1jMCJ3xB9k5YVTkZcnYw5T_Ac6yJzF-xxiXkrHH2RlhRMyLOTvPfl13thmgM4C8RdW3W3JFXqPFav1xCusUdFejT59vCFpA5_f3PcRjqxraodF79xPQqvU7192htz4mnQ4th1RUOqkG9MXFHXId0mh1gNrFLbr1_XHQd0-zR1Y3EZ6d4kX29f27dfUhX94srqurZW6olPucywJjAoaVlFjCJOWmpgakKAjU6TVSaAu8BiH0xtbCcq610IRbBqQkc3qR5ZNuPEA_bFQfXKvDvfLaqVNrlzJQTLCCF4m_nPg--B8DxL1qXTTQNLoDP0RVpv-wApcJLCbQBB9jAPtXmmA1mqRGD9TogUomKUIVT0MvTurDpoX638jJlQS8PAE6Gt3YkC7p4n-coJyJcfuridu6u-3BBVDmePMAEXQw2-O6cS_9DUwnpcM</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>ALEXANDRIE, Anna-Karin</creator><creator>NYBERG, Fredrik</creator><creator>WARHOLM, Margareta</creator><creator>RANNUG, Agneta</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20040601</creationdate><title>Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population</title><author>ALEXANDRIE, Anna-Karin ; NYBERG, Fredrik ; WARHOLM, Margareta ; RANNUG, Agneta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-692001ec5731f15936cd3ce9821ed982c98afe6de88abfd8f66aa8a16f5e17143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - epidemiology</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Case-Control Studies</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NAD(P)H Dehydrogenase (Quinone) - genetics</topic><topic>Pneumology</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - genetics</topic><topic>Sweden - epidemiology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALEXANDRIE, Anna-Karin</creatorcontrib><creatorcontrib>NYBERG, Fredrik</creatorcontrib><creatorcontrib>WARHOLM, Margareta</creatorcontrib><creatorcontrib>RANNUG, Agneta</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALEXANDRIE, Anna-Karin</au><au>NYBERG, Fredrik</au><au>WARHOLM, Margareta</au><au>RANNUG, Agneta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>13</volume><issue>6</issue><spage>908</spage><epage>914</epage><pages>908-914</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>The major identified risk factor for lung cancer is tobacco smoking. We identified previously the possible modifying influence
of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population. The present study, extended by several study subjects and with
analyses for polymorphisms in GSTT1 and NQO1 , includes 524 lung cancer cases and 530 control subjects. No evidence for an influence of genetic polymorphisms in CYP1A1 , GSTM1 , GSTT1 , and NQO1 on lung cancer risk overall was found. In smokers, there was, however, a suggestion that the variant CYP1A1 and NQO1 genotypes may confer an increased risk for squamous cell carcinoma. In ever smokers, the homozygously deleted GSTM1 ( GSTM1*O/*O ) genotype was significantly associated with increased risk of small cell carcinoma (adjusted odds ratio 2.72, 95% confidence
interval 1.32-5.90). The risks noted for the variant CYP1A1 genotypes and the GSTM1*O/*O genotype seemed to be restricted to light smokers. The GSTT1*O/*O genotype also appeared to be a possible risk factor in light smokers, whereas, in heavy smokers, this genotype was associated
with decreased risk for lung cancer overall (odds ratio 0.36, 95% confidence interval 0.13-0.99). Due to the multiple comparisons
made, we cannot exclude the possibility that some of these associations may represent chance findings.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15184245</pmid><doi>10.1158/1055-9965.908.13.6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2004-06, Vol.13 (6), p.908-914 |
| issn | 1055-9965 1538-7755 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Small Cell - epidemiology Carcinoma, Small Cell - genetics Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Case-Control Studies Cytochrome P-450 CYP1A1 - genetics Dose-Response Relationship, Drug Female Genetic Predisposition to Disease Genotype Glutathione Transferase - genetics Humans Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Medical sciences Middle Aged NAD(P)H Dehydrogenase (Quinone) - genetics Pneumology Polymorphism, Genetic Risk Factors Smoking - adverse effects Smoking - genetics Sweden - epidemiology Tumors of the respiratory system and mediastinum |
| title | Influence of CYP1A1, GSTM1, GSTT1, and NQO1 Genotypes and Cumulative Smoking Dose on Lung Cancer Risk in a Swedish Population |
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