Mechanisms of cross-resistance between nucleoside analogues and vincristine or daunorubicin in leukemic cells

The aim of this study was to clarify the biochemical and molecular mechanisms behind the cross-resistance to nucleoside analogues (NAs) in four erythroleukemic cell lines with acquired resistance to the anthracycline daunorubicin and to the vinca alkaloid vincristine, expressing high levels of p-gly...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-07, Vol.320 (3), p.825-832
Hauptverfasser:	Löfgren, Christina, Hjortsberg, Linn, Blennow, Malin, Lotfi, Kourosh, Paul, Christer, Eriksson, Staffan, Albertioni, Freidoun
Format:	Artikel
Sprache:	eng
Schlagworte:	5 ′-Nucleotidase Anthracycline Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects arthracycline ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Cladribine Cytosine arabinoside Daunorubicin - pharmacology Deoxycytidine kinase Dose-Response Relationship, Drug Drug Resistance, Multiple - drug effects Humans K562 Cells MEDICIN MEDICINE Nucleosides - pharmacology p-Glycoprotein Vincristine - pharmacology
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