Serum lipids and hippocampal volume: The link to Alzheimer's disease?

The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High‐density lipo...

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Veröffentlicht in:	Annals of neurology 2004-11, Vol.56 (5), p.745-749
Hauptverfasser:	Wolf, Henrike, Hensel, Anke, Arendt, Thomas, Kivipelto, Miia, Winblad, Bengt, Gertz, Hermann-Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - pathology Analysis of Variance Biological and medical sciences Cholesterol, HDL - blood Cholesterol, LDL - blood Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - pathology Humans Lipids - blood Male Medical sciences Medicin och hälsovetenskap Nervous system (semeiology, syndromes) Neurology
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Zusammenfassung:	The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High‐density lipoprotein cholesterol, but not low‐density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high‐density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease. Ann Neurol 2004;56:745–749
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.20289