Expression of JNK Interacting Protein JIP-1 is Down-regulated in Liver from Mouse Embryos with a Disrupted Insulin-like Growth Factor II Gene
JNK interacting Protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. Its expression pattern in murine tissue indicates that JIP-1 has a role in the regulation of different cellular events. By examining the JIP-1 expression in transgenic mice that were heterozygous for a...
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Veröffentlicht in: | In vivo (Athens) 2004-09, Vol.18 (5), p.643-647 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | JNK interacting Protein 1 (JIP-1) is a pivotal scaffolding protein in the JNK signalling pathway. Its expression pattern in
murine tissue indicates that JIP-1 has a role in the regulation of different cellular events. By examining the JIP-1 expression
in transgenic mice that were heterozygous for a functional insulin-like growth factor II (igf-2) gene, it was possible to
show that an abrogated igf-2 expression was followed by a decreased transcription of the JIP-1 gene. This pattern was consistent
through different litters, which suggests that the up- or down-regulation of JIP-1 may well be part of the intracellular mediation
of IGF II induced messages. |
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ISSN: | 0258-851X 1791-7549 |