Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

The mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereo...

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Veröffentlicht in:	Brain research 2005-02, Vol.1033 (2), p.216-220
Hauptverfasser:	Aguirre, Jose A., Kehr, Jan, Yoshitake, Takashi, Liu, Fang-Ling, Rivera, Alicia, Fernandez-Espinola, Sergio, Andbjer, Beth, Leo, Giuseppina, Medhurst, Andrew D., Agnati, Luigi F., Fuxe, Kjell
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal ganglia Biological and medical sciences Cell Proliferation - drug effects Corpus Striatum - drug effects Corpus Striatum - metabolism DA metabolism Dopamine - metabolism Male Medical sciences Medicin och hälsovetenskap Metabotropic glutamate receptor mGluR5 Mice Mice, Inbred C57BL MPTP MPTP Poisoning - metabolism MPTP Poisoning - prevention & control Neurons - drug effects Neurons - metabolism Neuropharmacology Neuroprotection Neuroprotective agent Pharmacology. Drug treatments Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Pyridines - administration & dosage Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism Stereology Substantia Nigra - drug effects Substantia Nigra - metabolism
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Zusammenfassung:	The mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereological analysis of TH immunoreactivity and microdensitometry. Biochemical analysis showed no restoration of DA levels and metabolism indicating a maintained reduction of DA transmission.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2004.11.040