Impaired Absorption of Insulin Aspart From Lipohypertrophic Injection Sites

Johansson et al investigate whether the absorption of a single subcutaneous dose of insulin aspart is impaired when administered to lipohypertrophic tissue in patients with type 1 diabetes. They found that the absorption of insulin aspart was impaired in lipohypertrophic tissue, yielding a 25% lower Cmax of plasma insulin. They believe that it is likely to be of clinical importance.