Stroke mortality and the apoB/apoA‐I ratio: results of the AMORIS prospective study

. Objectives. LDL cholesterol is a well‐established risk factor for myocardial infarction, but not for stroke. The main objective of the present study was to determine if the risk of stroke is related to the balance between the proatherogenic apoB lipoprotein particles and the antiatherogenic apoA‐I particles as is the case for myocardial infarction. Subjects and design. A total of 98 722 men and 76 831 women were recruited from screening programmes. The prospective risk and the relationships between five different types of fatal strokes and the lipid fractions, apoB, apoA‐I and the apoB/apoA‐I ratio (automated immunoturbidimetry) were examined. The results were compared with the risks of other ischaemic and non‐ischaemic fatalities. Results. Mean follow‐up was 10.3 years. High apoB and low apoA‐I values were significantly related to risk of stroke. The odds ratio comparing the upper 10th versus the 1st decile of the apoB/apoA‐I ratio for all strokes adjusted for age, gender, total cholesterol (TC) and triglycerides (TG) was 2.07 (95% CI: 1.49–2.88), P