Are estrogen receptor content in breast cancer and effects of tamoxifen on sex hormone-binding globulin markers for individual estrogen sensitivity?

Individual women differ with respect to their sensitivity to estrogen and serum levels of sex hormone-binding globulin (SHBG) may reflect the individual response. We found a significant correlation between estrogen receptor (ER) concentrations in breast cancer tissue and SHBG levels during tamoxifen...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2006-04, Vol.99 (1), p.76-79
Hauptverfasser:	Löfgren, L., von Schoultz, E., Fernstad, R., von Schoultz, B., Carlström, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor Breast cancer Breast Neoplasms - metabolism ER concentrations Estrogen sensitivity Estrogens - physiology Female Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Medicin och hälsovetenskap Middle Aged Receptors, Estrogen - metabolism Selective Estrogen Receptor Modulators - pharmacology Sex Hormone-Binding Globulin - metabolism SHBG Tamoxifen Tamoxifen - pharmacology Tumors Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	Individual women differ with respect to their sensitivity to estrogen and serum levels of sex hormone-binding globulin (SHBG) may reflect the individual response. We found a significant correlation between estrogen receptor (ER) concentrations in breast cancer tissue and SHBG levels during tamoxifen treatment. Estrogen sensitivity may be a general characteristic common to various organs and different between individual women.
ISSN:	0960-0760 1879-1220
DOI:	10.1016/j.jsbmb.2005.11.010