Identification and Evaluation of Potential Anti-cancer Drugs on Human Neuroendocrine Tumor Cell Lines

The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. Materials and Methods: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines...

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Veröffentlicht in:	Anticancer research 2006-11, Vol.26 (6B), p.4125-4129
Hauptverfasser:	LARSSON, Dhana E, LÖVBORG, Henrik, RICKARDSON, Linda, LARSSON, Rolf, ÖBERG, Kjell, GRANBERG, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Biological and medical sciences Cell Line, Tumor Drug Screening Assays, Antitumor Drug sensitivity FMCA Humans Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Neuroendocrine tumors Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - pathology Tumors
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Beschreibung
Zusammenfassung:	The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. Materials and Methods: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. Results: The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC 50 values
ISSN:	0250-7005 1791-7530 1791-7530